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TranscriptomicsMicroRNA expression profiling of male breast cancer
To test the hypothesis that there is a specific miRNA expression signature which characterizes male breast cancers, we performed miRNA microarray analysis in a series of male breast cancers and compared them to cases of male gynecomastia and female breast cancers miRNA microarray analysis was perfor...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-17155 | biostudies-arrayexpress
TranscriptomicsMale breast cancer copy number profiles
Exploratory study of copy number profiles of male breast cancer patients. The experiment contains 75 male breast cancer samples, analysed on a 135K whole genome CGH array
ORGANISM(S): Homo sapiens 
2015-09-13 | E-GEOD-57087 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human male and female breast cancers
Gene expression profiling of male and female breast cancer samples
ORGANISM(S): Homo sapiens 
2010-07-29 | E-TABM-810 | biostudies-arrayexpress
TranscriptomicsHigh-resolution aCGH analyses of copy number alterations in HER2-amplified breast cancer
HER2 gene amplification and protein overexpression (HER2+) define a clinically challenging subgroup of breast cancer with variable prognosis and response to therapy. Although gene expression profiling has identified an ERBB2 molecular subtype of breast cancer, it is clear that HER2+ tumors reside in...
ORGANISM(S): Homo sapiens 
2010-04-14 | E-GEOD-21259 | biostudies-arrayexpress
TranscriptomicsDiscovery cohort for genomic predictor of response and survival following neoadjuvant taxane-anthracycline chemotherapy in breast cancer
PURPOSE: To develop a predictive test for response and survival following neoadjuvant taxane-anthracycline chemotherapy for HER2-negative invasive breast cancer. METHODS: We developed a microarray-based gene expression test from pre-treatment tumor biopsies (310 patients) to predict favorable outcom...
ORGANISM(S): Homo sapiens 
2011-05-11 | E-GEOD-25055 | biostudies-arrayexpress
TranscriptomicsBreast Cancer Methylomes Establish an Epigenomic Foundation for Metastasis
Cancer-specific changes in DNA methylation can alter genetic stability, genomic structure, and gene expression. Promoter CpG island methylation can result in transcriptional silencing and plays an important role in the oncogenic process. We used genome-wide analysis to characterize the methylomes o...
ORGANISM(S): Homo sapiens 
2011-03-31 | E-GEOD-26349 | biostudies-arrayexpress
TranscriptomicsThe retinoblastoma gene is targeted for rearrangements in BRCA1-deficient basal-like breast cancer.
Breast tumors from BRCA1 germ line mutation carriers typically exhibit features of the basal-like molecular subtype. However, the specific genes recurrently mutated as a consequence of BRCA1 dysfunction have not been fully elucidated. In this study, we utilized gene expression profiling to molecular...
ORGANISM(S): Homo sapiens 
2012-06-26 | E-GEOD-25307 | biostudies-arrayexpress
ProteomicsIntegrated analysis of label-free quantitative proteomics and bioinformatics reveal insights into signaling pathways in male breast cancer
The project contains raw and result files from a proteomic profiling of a male breast cancer (MBC) case. Label-free quantification-mass spectrometry (LFQ-MS) and bioinformatics analysis were employed to investigate the differentially expressed proteins (DEPs) among distinct tissue samples: the prima...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD012453 | Pride
Proteomics Signaling pathways Label-free mass spectrometry Bioinformatics analysis Male breast cancer 
TranscriptomicsHigh resolution array-CGH and expression profiling identifies a novel genomic subtype of ER negative breast cancer
An oligo array based high-resolution analysis of copy number alterations in 171 primary breast tumors of relatively small size and low NPI, and 49 breast cancer cell-lines. Objectives of the study were to study the molecular taxonomy and the genomic aberration patterns in a breast cancer cohort repr...
ORGANISM(S): Homo sapiens 
2007-08-16 | E-GEOD-8757 | biostudies-arrayexpress
TranscriptomicsAnalysis of Promoter Methylation in Breast Cancer
Promoter methylation was assayed in a number of breast cancer and control normal samples along with the effects of 5'-aza-2'-deoxycytidine on breast cancer cell line transcriptomes. Aberrant promoter hypermethylation is frequently observed in cancer. The potential for this to contribute to tumour d...
ORGANISM(S): Homo sapiens 
2011-03-07 | E-GEOD-26990 | biostudies-arrayexpress
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