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TranscriptomicsSingle-cell transcriptional profiling of young-adult and aging (middle-aged) mouse anterior pituitary in steady-state conditions and after transgenically inflicted local damage
Adult pituitary stem cells (SC) are mainly dormant, yet in the case of damage the resident SC compartment shows swift activation. More in particular, following diphtheria toxin (DT)-triggered endocrine cell-ablation injury in the GHCre/iDTR mouse model (expressing the Cre recombinase under control o...
ORGANISM(S): Mus musculus 
2021-06-15 | E-MTAB-10021 | biostudies-arrayexpress
TranscriptomicsSingle-Cell RNA Sequencing of Mouse Synovial Tissue Across Developmental Time Points
Synovial joints harbor a protective lining layer, consisting of fibroblasts and macrophages, which form an epithelial-like barrier. In inflamed joints, lining macrophages regulate both early inflammatory cell influx and resolution. Despite these critical functions, it is currently unknown at what st...
ORGANISM(S): Mus musculus 
2026-06-09 | E-MTAB-17170 | biostudies-arrayexpress
TranscriptomicsEvaluation of a chimeric YF-ZIK vaccine candidate in rhesus macaques
In this study, we designed and assessed the immunogenicity and protective efficacy of a chimeric live-attenuated vaccine derived from the yellow fever 17D (YF17D) backbone engineered to express ZIKV antigens. We immunized rhesus macaques with two subcutaneous doses, which rapidly induced neutralizin...
ORGANISM(S): Macaca mulatta 
2025-10-28 | E-MTAB-15887 | biostudies-arrayexpress
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