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MetabolomicsMuscle metabolic resilience and enhanced exercise adaptation by Esr1-induced remodeling of mitochondrial cristae-nucleoid architecture in males

Reduced estrogen action is associated with obesity and insulin resistance. However, the cell and tissue-specific actions of estradiol in maintaining metabolic health remain inadequately understood, especially in men. We observed that skeletal muscle ESR1/Esr1 (encodes estrogen receptor α) is posi...

2025-04-09 | MTBLS914 | MetaboLights
MetabolomicsAcute heat stress amplifies exercise-induced metabolomic perturbations and reveals variation in circulating amino acids in endurance-trained males

Using untargeted metabolomics, we aimed to characterise the systemic impact of environmental heat stress during exercise. Twenty-three trained male triathletes completed a 30-min exercise test in hot (35°C) and temperate (21°C) conditions. Venous blood samples were collected immediately pre- and ...

2025-08-14 | MTBLS6051 | MetaboLights
MetabolomicsSingle-cell RNA sequencing decipher hepatic injury and APOA4 as a biomarker in males with intrauterine growth restriction

Intrauterine growth restriction (IUGR) is associated with increased relative liver weight at birth, hepatic function decline and a higher risk for chronic liver and cardiovascular diseases in adults. Precise mechanisms of early developmental plasticity to intervene in poor fetal programming and a...

2023-09-25 | MTBLS6881 | MetaboLights
TranscriptomicsGene expression analysis of eight-cell stage rat embryos sired by paternally exposed males to saline or BEP
8-cell stage rat embryos were sired by males treated with saline or a chemotherapeutic cocktail, BEP, consisting of Bleomycin, Etoposide, and Cisplatin for 9 weeks. Animals were given an additional 9 weeks of recovery, without any treatment, prior to mating. qPCR gene expression profiling for 84 ste...
ORGANISM(S): Rattus norvegicus 
2014-03-13 | E-GEOD-55842 | biostudies-arrayexpress
TranscriptomicsCombinatory microarray and SuperSAGE analyses identify pairing-dependently transcribed genes in Schistosoma mansoni males, such as follistatin [Microarray]
Transcriptional profiling of S. mansoni pairing-experienced males (EM) vs. pairing unexperienced males (UM) Two conditions (EM vs. UM) with three biological samples of EM and in parallel other three biological samples of UM. For each sample (three EM and three UM) were performed four technical rep...
ORGANISM(S): Schistosoma mansoni 
2013-09-09 | E-GEOD-44193 | biostudies-arrayexpress
TranscriptomicsA systematic search for transgenerational effect of drug exposure to adult males using a novel Drosophila model
Drosophila melanogaster adult flies fed on food containing 16 mg/ml of pentylenetetrazole (PTZ) in the food show a hyperkinetic behavior within 24 hours. Half of that concentration, i.e., 8 mg/ml, of PTZ, if fed for seven days, though doesn’t cause seizure-like behavior, results in a decreased climb...
ORGANISM(S): Drosophila melanogaster 
2009-03-25 | E-GEOD-15136 | biostudies-arrayexpress
TranscriptomicsMicroarray on mock-treated or Orsay virus infected males and hermaphrodites of Caenorhabditis elegans
This experiment investigates changes in gene expression upon Orsay virus infection and between males and hermaphrodites in the nematode Ceanorhabditis elegans. The laboratory reference strain N2 was used. For this strain, males are less susceptible to Orsay virus infection than hermaphrodites. The g...
ORGANISM(S): Caenorhabditis elegans 
2020-09-13 | E-MTAB-9561 | biostudies-arrayexpress
ProteomicsSchistosoma mansoni Excretroy/Secretory Products from adult males and females
In the present study we compare the secretome from S. mansoni adult males and females using a label free quantitative proteomic approach
ORGANISM(S): Schistosoma mansoni (Blood fluke) 
2022-06-07 | PXD030699 | Pride
Schistosoma Adults Esp Es Secretome Males Females 
TranscriptomicsTranscription profiling of Drosophila abdomen from females mated with sex peptide null or sex peptide producing males
Comparison of females mated to males null for Sex-Peptide (SP0, Liu, H. and E. Kubli, Sex-peptide is the molecular basis of the sperm effect in Drosophila melanogaster. Proc Natl Acad Sci U S A, 2003. 100(17): p. 9929-33) or to control, Sex-Peptide producing, males. Comparisons were made at 3 and 6 ...
ORGANISM(S): Drosophila melanogaster 
2009-08-01 | E-MEXP-2074 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Drosophila head and thorax from females mated with sex peptide null or sex peptide producing males
Comparison of females mated to males null for Sex-Peptide (SP0, Liu, H. and E. Kubli, Sex-peptide is the molecular basis of the sperm effect in Drosophila melanogaster. Proc Natl Acad Sci U S A, 2003. 100(17): p. 9929-33) or to control, Sex-Peptide producing, males. Comparisons were made at 3 and 6 ...
ORGANISM(S): Drosophila melanogaster 
2009-08-01 | E-MEXP-2070 | biostudies-arrayexpress
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