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TranscriptomicsThymic XCR1+ dendritic cells undergo a functional maturation irrespective of type I interferon and of the microflora
Dendritic cells (DC) play critical roles in central and peripheral T cell tolerance. DC found in the steady-state periphery undergo an homeostatic, tolerogenic, maturation that promotes interaction with naive T cells and induction of abortive responses. In contrast, thymic DC are thought to exist so...
ORGANISM(S): Mus musculus 
2016-08-22 | E-GEOD-78171 | biostudies-arrayexpress
UnknownA Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation.
Not available
S-EPMC4954684 | biostudies-literature
TranscriptomicsThymic XCR1+ dendritic cells undergo a functional maturation fundamentally similar to that of peripheral tolerogenic XCR1+ dendritic cells
Dendritic cells (DC) play critical roles in central and peripheral T cell tolerance. DC found in the steady-state periphery undergo an homeostatic, tolerogenic, maturation that promotes interaction with naive T cells and induction of abortive responses. In contrast, thymic DC are thought to exist so...
ORGANISM(S): Mus musculus 
2016-08-22 | E-GEOD-71166 | biostudies-arrayexpress
TranscriptomicsEffect of scarification on gene expression in the skin of C57BL/6 mice
To study the effects of scarification on gene expression in the skin we performed microarray analysis on intact skin (control) and skin collected 2 h after scarification. Comparison of microarray data between the two groups showed that 451 probe sets (1.0% of a total 45038 probe sets on the arrays) ...
ORGANISM(S): Mus musculus 
2012-03-01 | E-GEOD-34955 | biostudies-arrayexpress
TranscriptomicsQuantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub
The aim of the dataset was to study on a genome-wide level the impact of Lat deficiency on gene expression in resting and activated CD4+ T cells Lat+ and Lat? CD4+ T cells were isolated from lymph nodes and spleen of Latfl-dtr Tmat-Cre mice using a Dynabeads untouched mouse CD4 cells kit (Life Techn...
ORGANISM(S): Mus musculus 
2014-03-02 | E-GEOD-49507 | biostudies-arrayexpress
UnknownIntranasally administrated fusion-inhibitory lipopeptides block SARS-CoV-2 infection in mice and enable long-term protective immunity.
Not available
S-EPMC11735783 | biostudies-literature
TranscriptomicsBroad and largely overlapping molecular changes arise in thymic and peripheral XCR1+ dendritic cells upon tolerogenic and immunogenic maturation [reanalyzed samples]
This series contains re-analyzed samples from GSE39555, GSE39556 and GSE15907. DC were isolated from lymphoid organs as previously described (Vremec et al., 2000). Normalized data are available on the SuperSeries record, GSE71171.
ORGANISM(S): Mus musculus 
2016-08-22 | E-GEOD-71170 | biostudies-arrayexpress
UnknownMolecularly matched targeted therapy: a promising approach for refractory metastatic melanoma.
Not available
S-EPMC11379651 | biostudies-literature
UnknownErythropoietin receptor on cDC1s dictates immune tolerance.
Not available
S-EPMC12929016 | biostudies-literature
GenomicsSite- and allele-specific de-silencing of polycomb repressive activity by insertional oncogenesis: a new recurrent mechanism of TAL1 activation in T-ALL
T-cell acute lymphoblastic leukemia’s (T-ALL) are malignant proliferations of thymocytes occurring through a large diversity of genomic and epigenetic alteration. TAL1 is amongst the most frequently deregulated oncogenes. Known TAL1 dysregulation mechanisms consist of t(1;14) translocations and SIL...
ORGANISM(S): Homo sapiens 
2014-07-10 | E-GEOD-59257 | biostudies-arrayexpress
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