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ProteomicsSLP76 interactome in resting and activated primary mast cells
We used a knock-in (KI) mouse expressing SLP-76 with a C-terminal One-Strep-Tag (OST). Such a system allowed the replacement in the genome of SLP-76 by its tagged version and its expression in physiological amounts. Then, by combining high affinity purification and label-free quantitative proteomics...
ORGANISM(S): Mus musculus (Mouse) 
2013-08-28 | PXD000052 | Pride
Interactomics Slp76 Quantitative mass spectrometry 
UnknownUnveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal.
Not available
S-EPMC5881467 | biostudies-literature
TranscriptomicsQuantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub
The aim of the dataset was to study on a genome-wide level the impact of Lat deficiency on gene expression in resting and activated CD4+ T cells Lat+ and Lat? CD4+ T cells were isolated from lymph nodes and spleen of Latfl-dtr Tmat-Cre mice using a Dynabeads untouched mouse CD4 cells kit (Life Techn...
ORGANISM(S): Mus musculus 
2014-03-02 | E-GEOD-49507 | biostudies-arrayexpress
GenomicsSite- and allele-specific de-silencing of polycomb repressive activity by insertional oncogenesis: a new recurrent mechanism of TAL1 activation in T-ALL
T-cell acute lymphoblastic leukemia’s (T-ALL) are malignant proliferations of thymocytes occurring through a large diversity of genomic and epigenetic alteration. TAL1 is amongst the most frequently deregulated oncogenes. Known TAL1 dysregulation mechanisms consist of t(1;14) translocations and SIL...
ORGANISM(S): Homo sapiens 
2014-07-10 | E-GEOD-59257 | biostudies-arrayexpress
GenomicsThe immunopathological landscape of human pre-TCRα deficiency: from rare to common variants
The immunopathological landscape of human pre-TCRα deficiency: from rare to common variants
PRJNA1020588 | ENA
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