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MetabolomicsTFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoske...
2022-06-23 | MTBLS4307 | MetaboLights
ProteomicsMalonylation of Nucleolin Promotes Cell Proliferation in Hepatocarcinoma cells by enhancing AKT translation
Cancer cells undergo metabolic reprogramming that is intricately linked to malignancy. Protein acylation is especially responsive to metabolic changes, influencing signal transduction pathways and fostering cell proliferation. However, the role of malonylation in cancer remains poorly understood. In...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD048727 | Pride
Malonylation cancer hepatocellular 
UnknownNucleolin malonylation as a nuclear-cytosol signal exchange mechanism to drive cell proliferation in Hepatocarcinoma by enhancing AKT translation.
Not available
S-EPMC11525140 | biostudies-literature
UnknownDeciphering a profiling based on multiple post-translational modifications functionally associated regulatory patterns and therapeutic opportunities in human hepatocellular carcinoma.
Not available
S-EPMC11681642 | biostudies-literature
UnknownComprehensive analysis of protein post-translational modifications reveals PTPN2-STAT1-AOX axis-mediated tumor progression in hepatocellular carcinomas.
Not available
S-EPMC11788854 | biostudies-literature
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