Sort   by:  
 Page size 
ProteomicsSubstrate profiling of the metalloproteinase ovastacin – Implications for its physiological function in mammalian fertilization
The metalloproteinase ovastacin is released by the mammalian oocyte upon fertilization and cleaves zona pellucida protein 2, a component of the surrounding extracellular matrix, at a distinct cleavage site. This limited proteolysis hardens the zona pellucida, abolishes sperm binding and thereby regu...
ORGANISM(S): Mus Musculus (mouse) 
2023-09-15 | PXD038561 | JPOST Repository
TranscriptomicsA Restricted Role for Sperm-borne MicroRNAs in Mammalian Fertilization
Prototypical micro RNAs (miRNAs) are 21~25-base-pair RNAs that regulate differentiation, carcinogenesis and pluripotency by eliminating mRNAs or blocking their translation, processes collectively termed RNA interference (RNAi). RNAi mediated by miRNAs regulates early development in zebrafish, and mo...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-4011 | biostudies-arrayexpress
TranscriptomicsTranscriptome partitioning in mouse fertilization.
RNA transcripts are distributed non-uniformly in the oocytes of many animals, such that newly-divided embryo cells (blastomeres) inherit distinct transcriptomes following fertilization. In animals such as the frog, Xenopus laevis, programmed transcript regionalization directs early embryonic axis fo...
ORGANISM(S): Mus musculus 
2011-04-21 | E-GEOD-27396 | biostudies-arrayexpress
ProteomicsShotgun proteomics Identifies Molecular Signatures of Hydrosalpinx
Subsequent to pelvic inflammatory diseases fallopian tube developed Hydrosalpinx, which is characterized as an enlarged occluded tube filled with fluid. Hydrosalpinx has adverse effects on tubal physiology and has been detrimental to success of in vitro fertilization (IVF). To assess molecular alter...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-20 | MSV000081727 | MassIVE
TranscriptomicsMicroarray analysis of transcription changes in zebrafish embryos of different developmental ages after exposure to cyanide.
Zebrafish embryos are significantly more resistant to cyanide exposure at 24 h post fertilization than at 7 days post fertilization. In this experiment we examined the transcriptional response to cyanide exposure at both ages.
ORGANISM(S): Danio rerio 
2018-06-08 | E-MTAB-6311 | biostudies-arrayexpress
GenomicsA unique regulatory phase of DNA methylation in the early mammalian embryo
DNA methylation is highly dynamic during mammalian embryogenesis. It is broadly accepted that the paternal genome is actively depleted of global cytosine methylation at fertilization, followed by passive depletion that reaches a minimum at the blastocyst stage. However, this model is based on limit...
ORGANISM(S): Mus musculus 
2012-03-28 | E-GEOD-34864 | biostudies-arrayexpress
UnknownFertilization triggers early proteomic symmetry breaking in mammalian embryos.
Not available
S-EPMC12712633 | biostudies-literature
GenomicsA Restricted Role for Sperm-borne MicroRNAs in Mammalian Fertilization
Prototypical micro RNAs (miRNAs) are 21~25-base-pair RNAs that regulate differentiation, carcinogenesis and pluripotency by eliminating mRNAs or blocking their translation, processes collectively termed RNA interference (RNAi). RNAi mediated by miRNAs regulates early development in zebrafish, and mo...
ORGANISM(S): Mus musculus 
2006-09-06 | GSE4011 | GEO
ProteomicsChaperonin TRiC bridges radial spokes for folding proteins locally translated in mammalian sperm flagella
As animals evolved from external to internal fertilization, sperm flagella, which once transiently propelled sperm in water to reach nearby eggs, developed to beat for days or even longer within the female reproductive tract. How flagella were remodeled accordingly remains unclear. Unlike externally...
ORGANISM(S): Bos Taurus 
PXD067693 |
UnknownTMEM95 is a sperm membrane protein essential for mammalian fertilization.
Not available
S-EPMC7295574 | biostudies-literature
Sort   by:  
 Page size