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MetabolomicsLactation-related metabolic mechanism investigated based on mammary gland metabolomics and 4 biofluids’ metabolomics relationships in dairy cows

BACKGROUND: Lactation is extremely important for dairy cows; however, the understanding of the underlying metabolic mechanisms is very limited. This study was conducted to investigate the inherent metabolic patterns during lactation using the overall biofluid metabolomics and the...

2018-03-16 | MTBLS411 | MetaboLights
MetabolomicsSilage-derived flavonoids reprogram rumen microbiota to improve milk fat synthesis via rumen-mammary gland axis

Inoculation with homofermentative lactic acid bacteria (LAB) effectively enhances the silage quality of forages. Moreover, feeding such LAB-inoculated silage modulates rumen microbiota composition and metabolites, thereby improving ruminant production performance. Nevertheless, the specific mecha...

2026-01-11 | MTBLS13651 | MetaboLights
MetabolomicsSilage-derived flavonoids reprogram rumen microbiota to improve milk fat synthesis via rumen-mammary gland axis

Inoculation with homofermentative lactic acid bacteria (LAB) effectively enhances the silage quality of forages. Moreover, feeding such LAB-inoculated silage modulates rumen microbiota composition and metabolites, thereby improving ruminant production performance. Nevertheless, the specific mecha...

2026-01-10 | MTBLS13648 | MetaboLights
TranscriptomicsTranscriptomic Analysis of Embryonic Mammary Cells
The mammary primordium represents the earliest evidence of commitment to the mammary lineage. The primordium forms via inductive tissue interactions between its constitutive tissues, the mesenchyme and epithelium. Here, we describe an analysis of the transcriptome of the mammary bud epithelium and i...
ORGANISM(S): Mus musculus 
2011-11-11 | E-TABM-1099 | biostudies-arrayexpress
TranscriptomicsECM-dependent gene expression in normal and tumor-derived mammary organoids
A critical step in metastasis is cancer cell dissemination. Dissemination and metastasis are associated with specific genetic changes and changes in extracellular matrix (ECM), but how these changes interact to enable dissemination remains unclear. Here we tested the importance of ECM to disseminat...
ORGANISM(S): Mus musculus 
2012-08-16 | E-GEOD-39173 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse normal mammary gland epithelial populations: basal/myoepithelial, luminal estrogen receptor negative (ER-) and luminal estrogen receptor positive (ER+) cells
The goal of the experiment was to carry out a transcriptome analysis of the three main epithelial cell populations of the mouse mammary gland, the basal/myoepithelial, luminal estrogen receptor negative (ER-) and luminal estrogen receptor positive (ER+) cells, to identify cell-type specific differen...
ORGANISM(S): Mus musculus 
2009-04-20 | E-TABM-683 | biostudies-arrayexpress
GenomicsAn epigenetic memory of pregnancy in the mouse mammary gland
Pregnancy is the major modulator of mammary gland activity. It induces a tremendous expansion of the mammary epithelium and the generation of alveolar structures for milk production. Anecdotal evidence from multiparous humans indicates that the mammary gland may react less strongly to the first preg...
ORGANISM(S): Mus musculus 
2015-05-15 | E-GEOD-67386 | biostudies-arrayexpress
TranscriptomicsThe gain-of-function AKT1E17K allele is oncogenic in mouse mammary gland
The gain-of-function mutation in the pleckstrin homology domain of AKT1 (AKT1E17K) occurs in lung and breast cancer. By use of human cellular models and of a AKT1E17K transgenic Cre-inducible murine strain (R26-AKT1E17K mice) we have demonstrated that AKT1E17K is a bona-fide oncogene for lung epithe...
ORGANISM(S): Mus musculus 
2022-06-01 | E-MTAB-7388 | biostudies-arrayexpress
TranscriptomicsCharacterisation of microRNA expression in post-natal mouse mammary gland development
Background: The differential expression pattern of microRNAs (miRNAs) during mammary gland development might provide insights into their role in regulating the homeostasis of the breast epithelium. Our aim was to analyse these regulatory functions by deriving a comprehensive tissue-specific combined...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-15057 | biostudies-arrayexpress
TranscriptomicsCharacterisation of microRNA expression in post-natal mouse mammary gland development [gene]
Background: The differential expression pattern of microRNAs (miRNAs) during mammary gland development might provide insights into their role in regulating the homeostasis of the breast epithelium. Our aim was to analyse these regulatory functions by deriving a comprehensive tissue-specific combined...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-15054 | biostudies-arrayexpress
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