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TranscriptomicsCharacterisation of microRNA expression in post-natal mouse mammary gland development
Background: The differential expression pattern of microRNAs (miRNAs) during mammary gland development might provide insights into their role in regulating the homeostasis of the breast epithelium. Our aim was to analyse these regulatory functions by deriving a comprehensive tissue-specific combined...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-15057 | biostudies-arrayexpress
TranscriptomicsCharacterisation of microRNA expression in post-natal mouse mammary gland development [gene]
Background: The differential expression pattern of microRNAs (miRNAs) during mammary gland development might provide insights into their role in regulating the homeostasis of the breast epithelium. Our aim was to analyse these regulatory functions by deriving a comprehensive tissue-specific combined...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-15054 | biostudies-arrayexpress
TranscriptomicsCharacterisation of microRNA expression in post-natal mouse mammary gland development [miRNA]
Background: The differential expression pattern of microRNAs (miRNAs) during mammary gland development might provide insights into their role in regulating the homeostasis of the breast epithelium. Our aim was to analyse these regulatory functions by deriving a comprehensive tissue-specific combined...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-15055 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse day 0 versus day 1 involuting mammary gland
Mammary gland involution represents one of the most dramatic examples of programmed cell death/apoptosis and tissue regression during development, yet large gaps still exist in the understanding of the mechanisms involved, and the key factors that trigger involution, are not yet identified. With the...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5317 | biostudies-arrayexpress
TranscriptomicsExpression data from an involution time course in wild type and E2F3 +/- mice.
We have compared an involution timecourse for wild type and E2F3 heterozygous mice on the Operon 3.0 platform. Three mice were taken for each genotype at each timepoint (Involution day 0, 1, 2, 3 and 4) and RNA was prepared from the mammary glands. The RNA from each mouse was pooled and run as an ...
ORGANISM(S): Mus musculus 
2008-07-11 | E-GEOD-11066 | biostudies-arrayexpress
TranscriptomicsmRNA Expression Comparison Between Igfbp7-null and wild type mice at Lactation Day 3
Insulin like growth factor binding protein 7, Igfbp7, is a secreted protein that in addition to modulating insulin and insulin-like growth factor signaling, it acts as a tumor suppressor gene in breast and other cancers. To elucidate the role of Igfbp7 in regulating the proliferation and differentia...
ORGANISM(S): Mus musculus 
2014-09-02 | E-GEOD-45118 | biostudies-arrayexpress
TranscriptomicsAnalysis of human breast milk cells: gene expression profiles during pregnancy, lactation, involution and mastitic infection.
The molecular processes underlying human milk production and the effects of mastitic infection are largely unknown because of limitations in obtaining tissue samples. Determination of gene expression in normal lactating women would be a significant step towards understanding why some women display p...
ORGANISM(S): Homo sapiens 
2016-04-01 | E-GEOD-77978 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of whole mammary glands from female mice at different developmental stages to identify transcripts that are differentially expressed in the mammary gland in wild type C57BL/6J mice.
This study was performed to identify transcripts that are differentially expressed in the mammary gland at 4 stages of developmental (virgin, pregnant, lactating and involution) in wild type C57BL/6J mice. Experiment Overall Design: Whole mammary glands No4 (inguinal) were obtained from female mice...
ORGANISM(S): Mus musculus 
2007-11-13 | E-GEOD-5831 | biostudies-arrayexpress
ProteomicsBovine milk proteome during involution
This project tested the hypothesis that drying off and involution is accompanied by similar changes among the low abundance proteins as mastitis, thereby presenting a possible alternative means of maximising yields of host-defence-associated bioactive proteins.
ORGANISM(S): Bos taurus (Bovine) 
2016-06-14 | PXD003110 | Pride
Involution Bovine Sds-page Lc/msms Milk 
TranscriptomicsInvolution day 2, mouse mammary gland Rac1 knockout mice.
The microarray was conducted from RNA isolated from mouse mammary glands harvested from Involution day 2 mice. Cre-mediated specific Rac1 gene deletion in luminal mammary epithelial cells was achieved by crossing Rac1fx/fxRosaYFP mice with WAPiCreTg/• mice to produce Rac1fx/fxYFP ;WAPiCreTg/• (...
ORGANISM(S): Mus musculus 
2016-10-31 | E-MTAB-5019 | biostudies-arrayexpress
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