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ProteomicsEndothelial senescence mediates hypoxia-induced vascular remodeling by modulating PDGFB expression
Uncontrolled accumulation of pulmonary artery smooth muscle cells (PASMC) to the distal pulmonary arterioles (PAs) is one of the major characteristics of pulmonary hypertension (PH). Cellular senescence contributes to aging and lung diseases associated with PH and links to PH progression. However, t...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-15 | PXD033549 | Pride
Twist1 Pulmonary hypertension Hypoxia Endothelial cell Pdgfb Senescence 
ProteomicsMechanical tension-induced spatial control of angiogenesis during lung regeneration
Mechanical forces altered after unilateral pneumonectomy (PNX) control post-PNX lung growth. Here we demonstrate that post-PNX vascular formation is stimulated at the peripheral region of the mouse lung requiring focal adhesion protein, paxillin, while inhibition of mechanical tension attenuates the...
ORGANISM(S): Mus musculus (Mouse) 
2026-10-19 | PXD038600 | Pride
Angiogenesis Angiopoietins Lung regeneration Paxillin Mechanical tension 
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