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OrbiSIMS is a recently developed instrument for label-free imaging of chemicals with micron spatial resolution and high mass resolution. We report a cryogenic workflow for OrbiSIMS (Cryo-OrbiSIMS) that improves chemical detection of lipids and other biomolecules in tissues. Cryo-OrbiSIMS boosts ioni...
2023-03-15 | MTBLS1873 | MetaboLights
Human HOS cell line was differentiated by beta-glycerophosphate (BGP) treatment and gene expression profiling was studied with Illumina expression microarray (HumanHT12_V4). Three negative control replicates vs. three BGP 3-day treatment replicates
ORGANISM(S): Homo sapiens 
A goal of this study was to identify and investigate previously unrecognized components of the remodeling process in the progression to heart failure by comparing gene expression in ischemic, failing (F) to non-failing (NF) hearts. These results also were compared to the changes observed in a prote...
ORGANISM(S): Homo sapiens 
Numerous RNA-binding proteins are arginine methylated and inhibition of arginine methylation triggers changes in alternative polyadenylation in cancer cells. Therefore we aimed to investigate whether this phenotype was also triggered in an untransformed cell line - RPE-1. RPE-1 cells were treated wi...
ORGANISM(S): Homo sapiens 
Numerous RNA-binding proteins involved in alternative polyadenylation are arginine methylation substrates. Therefore we aimed to study how alternative polyadenylation is impacted by preventing arginine methylation, and assess how conserved this phenotype is across a panel of cancer lines with differ...
ORGANISM(S): Homo sapiens 
There is a lack of comprehensive studies documenting the impact of sample collection conditions on metabolic composition of human urine. To address this issue, two experiments were performed at a three-month interval, in which midstream urine samples from healthy individuals were collected, pooled, ...
2014-12-18 | MTBLS148 | MetaboLights
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