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TranscriptomicsImmune Responses to Influenza-Like Illness
To investigate the nasal transcriptional response and peripheral plasmablast response in acute influenza infection 1. To investigate the nasal transcriptional response with real time PCR. 2. To measure plasmablast response by PPAb analysis.
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-64346 | biostudies-arrayexpress
TranscriptomicsPlasmablast response to influenza vaccines
To study the plasmablast response to influenza vaccines We want to test and see that LAIV, TIV and ID TIV induced different plasmablast response We take peripheral plasmablast and test its response to influenza vaccines at day 7 after vaccination. This array data set is for day 0 (before vaccines)
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-62110 | biostudies-arrayexpress
TranscriptomicsT cell responses to H1N1v and a longitudinal study of seasonal influenza vaccination - 2012
Systems biology approach to examine effects of seasonal flu vaccination in adults of different ages on gene expression, cytokine stimulation and serum cytokines with parameters such as immune senescence to uncover new markers and mechanisms behind failure of immune function in many older people. 1. ...
ORGANISM(S): Homo sapiens 
2014-12-25 | E-GEOD-64514 | biostudies-arrayexpress
TranscriptomicsHLA sensitization study
Immune profiles were performed retrospectively in highly sensitized kidney transplant candidates Our hypothesis was that baseline differences in immune profiles could help identify candidates that respond to desensitization therapy. Single-cell mass cytometry by time-of-flight (CyTOF) phenotyping, g...
ORGANISM(S): Homo sapiens 
2016-05-17 | E-GEOD-81454 | biostudies-arrayexpress
TranscriptomicsThe Immunobiology of Aging [II]
The overriding objective of this application is to seek funding for the development of a crossectional profile of immune phenotype of over 600 normal subjects between the ages of 50 and 90. As a consequence, we will infer changes in immune phenotype of normal subjects as they age. These immune pheno...
ORGANISM(S): Homo sapiens 
2015-11-07 | E-GEOD-74752 | biostudies-arrayexpress
GenomicsA Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging
Our data throw light upon the effect of WRN deficiency on gene expression and epigenomic modification, which indicates aging-associated changes from both genomic and epigenomic level. It was compared between WRN+/+ and WRN-/- in hESCs and hMSCs that the gene expression landscapes and epigenetic modi...
ORGANISM(S): Homo sapiens 
2015-05-13 | E-GEOD-52285 | biostudies-arrayexpress
GenomicsProgressive degeneration of human neural stem cells caused by pathogenic LRRK2
Aging and its physiological manifestations have been correlated with adult stem cell exhaustion and a failure to maintain tissue homeostasis1-10. Since multiple morphological cellular defects are associated with aging-related disorders, we hypothesized that late onset disorders might be linked to ad...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-34061 | biostudies-arrayexpress
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