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TranscriptomicsMicroarray analysis of HCT116 cells with and without a 1.4kb deletion
One of the strongest associated type 2 diabetes (T2D) loci reported to date resides within the TCF7L2 gene. Previous studies point to the T allele of rs7903146 in intron 3 as the causal variant at this locus. To aid in the identification of the actual gene(s) under the influence of this variant, we ...
ORGANISM(S): Homo sapiens 
2016-08-16 | E-MTAB-4839 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of endothelial cells from opposite sides of aortic valves from healthy adult male pigs
Differential transcriptional profiles from endothelial cells isolated from opposite sides of aortic valves from healthy adult male pigs (N=8, from slaughterhouse). Samples were hybridized to a human array and paired by animal.
ORGANISM(S): Sus scrofa 
2007-07-14 | E-CBIL-32 | biostudies-arrayexpress
Genomics4C and Capture-C in HCT116, NCM460 cells and colon tissue
One of the strongest associated type 2 diabetes (T2D) loci reported to date resides within the TCF7L2 gene. Previous studies point to the T allele of rs7903146 in intron 3 as the causal variant at this locus. To aid in the identification of the actual gene(s) under the influence of this variant, we ...
ORGANISM(S): Homo sapiens 
2016-08-15 | E-MTAB-4845 | biostudies-arrayexpress
GenomicsEpigenomic code in atherosusceptible endothelia: epigenomic regulation of HOX transcription factors by oxidative stress
Atherosclerosis preferentially develops in arterial regions where hemodynamic disturbed flow and oxidative stress are present. Epigenomic regulation, especially DNA methylation, plays an essential role in regulating gene expression in response to environmental factors. We investigated the DNA methyl...
ORGANISM(S): Sus scrofa 
2015-04-20 | E-MTAB-1930 | biostudies-arrayexpress
TranscriptomicsTranscriptional regulation of endocrine cell differentiation by Insm1
This experiment used RNA-Seq technology to explore gene expression in mouse Insm1^GFP/Pdx1^CFP HIGH [het/het] FACS sorted pancreatic cells (pre-beta cells) and Insm1^GFP/Pdx1^CFP LOW [het/het] cells (other endocrine progenitors) at E15.5 and E18.5. Comparison of Insm1 +/Pdx HIGH and Insm1 +/Pdx LO...
ORGANISM(S): Mus musculus 
2014-07-01 | E-MTAB-1929 | biostudies-arrayexpress
TranscriptomicsATAC-seq of HepG2 cells
ATAC-seq open chromatin maps for HepG2 cells (3 biological replicates), a liver model.
ORGANISM(S): Homo sapiens 
2019-03-20 | E-MTAB-7543 | biostudies-arrayexpress
TranscriptomicsPromoter capture-C of primary HepG2 cells
We employed a massively parallel, high resolution Capture-C based method to simultaneously characterize the genome-wide interactions of all human promoters in any cell type. We applied this approach to study the promoter interactome of HepG2 cells (3 biological replicates). We designed a custom Agil...
ORGANISM(S): Homo sapiens 
2019-03-20 | E-MTAB-7144 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of acinar cells from mice engineered with 3 TFs for reprogramming to beta cells
This experiment used RNA-Seq technology to explore gene expression in mouse FACS-purified pancreatic P60 Acinar cells, P60 Beta-cells, 1 day 3TF (MafA/Neurog3/Pdx1)-induced Acinar cells and 7 days 3TF-induced Acinar cells.ďż˝
ORGANISM(S): Mus musculus 
2016-07-06 | E-MTAB-3921 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of pig endothelium from multiple sites of coronary and non-coronary arteries
This study investigates the role of endothelial cell (EC) gene expression in the focal origin of atherosclerosis. The EC transcriptome was profiled in multiple arterial regions of normal swine. Specifically, small amounts of EC RNA were isolated from 7 athero-susceptible and 6 athero-protected regio...
ORGANISM(S): Sus scrofa 
2009-05-28 | E-CBIL-42 | biostudies-arrayexpress
TranscriptomicsRegional differences in left ventricular shear stress contribute to heterogenity of the endocardial transcriptome
The role of shear stress, the frictional force of blood flow, on the endothelium has been well documented. Differences in shear stress can have profound effects on endothelial and blood vessel biology. Endothelial cells (ECs), termed endocardial ECs, line the heart chambers and are exposed to comple...
ORGANISM(S): Sus scrofa 
2015-12-31 | E-MTAB-3669 | biostudies-arrayexpress
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