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ProteomicsAcute Myeloid Leukemia: a key role of DGKα and DGKζ in cell viability.
Acute myeloid leukemia (AML) is a heterogeneous disease presenting a relevant unmeet clinical need for new therapeutic drugs. We and others reported increased expression of various diacylglycerol kinases (DGK) in AML. Inhere we study the effect of ritanserin, a DGKα specific inhibitor and DGKζ-IN4 /...
ORGANISM(S): Homo sapiens (Human) 
2025-11-24 | PXD069537 | Pride
Acute myeloid leukemia Diacylglycerol kinases Ritanserin Proteome 
ProteomicsMulti-omics approach identifies a network of lipids and proteins associated to lysosomal and mitochondrial metabolism in Parkinson’s disease patients carrying mutations in TMEM175 gene.
Parkinson’s disease (PD) represents one of the most frequent neurodegenerative disorders for which clinically useful biomarkers remain to be identified and validated for early and more precise diagnosis or for differentiation of disease subtypes, which may require different treatments. In this study...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD049990 | Pride
Parkinson disease Multi-omics Tmem175 mutation 
ProteomicsCD99 modulates the proteomic landscape of Ewing sarcoma cells and related-extracellular vesicles.
Ewing sarcoma (EWS) is an aggressive pediatric bone tumor characterized by unmet clinical needs and an incompletely understood epigenetic heterogeneity. Here we considered CD99, a major surface molecule hallmark of EWS malignancy. Fluctuations of CD99 expression strongly impair cell dissemination, d...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD046846 | Pride
Ewing sarcoma  heterogeneity  proteomic  mass spectrometry  biomarkers  extracellular vesicles. 
MetabolomicsLarge-Scale Plasma Analysis Revealed New Mechanisms and Molecules Associated with the Host Response to SARS-CoV-2
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread to nearly every continent, registering over 1,250,000 deaths worldwide. The effects of SARS-CoV-2 on host targets remains largely limited, hampering our understanding of Coronavirus Disease 2019 (COVID-19) pathogenesis...
2021-11-04 | MTBLS1866 | MetaboLights
ProteomicsMolecular evaluation of different enrichment methods of extracellular vesicles from bio-banked serum from healthy subjects
Extracellular vesicles (EVs) from human body fluids are important tools for biomarker discovery and for exploring the mechanisms underlying different pathologies, including infectious diseases. The translation of EVs research into clinical practice is however hindered by the variability in EV pre-cl...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD068454 | Pride
Reproducibility Mass spectrometry Extracellular vesicles Proteomics 
ProteomicsLactobacillus Probiotic Cell-free Supernatants and Vitamin D Influence Interleukin-6 Production and Mitigate Oral Periodontopathogens-induced Cytotoxicity
Oral eubiosis is of utmost importance for local and systemic health. Consolidated habits, as excessive alcohol consumption, smoke, inappropriate oral hygiene, and western diet, exert detrimental effects on oral microbiota composition and function. This leads to caries, gingivitis, and periodontitis,...
ORGANISM(S): Lacticaseibacillus casei Limosilactobacillus reuteri Lacticaseibacillus rhamnosus 
2025-05-26 | PXD059098 | Pride
Mass-spectrometry Interleukin-6 Vitamin d Lactobacillus probiotic Proteomics 
ProteomicsEZH2 inhibition in mesothelioma cells increases the release of extracellular vesicles that skew neutrophils toward a pro-tumor phenotype.
BAP1-deficient pleural mesotheliomas have been shown to be sensitive to inhibition of the histone methyltransferase EZH2 in preclinical settings but only showed modest efficacy in clinical trials. We recently demonstrated that in BAP1-proficient mesothelioma cells, CDKN2A plays a crucial role in res...
ORGANISM(S): Homo sapiens (Human) 
2025-11-24 | PXD057566 | Pride
Mass spectrometry Pleural mesothelioma Spheroids. Histone methyltransferase ezh2 Cdkn2a Extracellular vesicles 
ProteomicsProgresses and challenges of Strongyloides spp. proteomics
The availability of high-quality data of helminth genomes provided over the last two decades has supported and accelerated large-scale ‘omics studies and, consequently, the achievement of a more in depth molecular characterisation of a number of pathogens. Strongyloides spp. are no less and since th...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD041218 | Pride
Immunoproteomics Strongyloidiasis Excretory/secretory product (esp) Proteomics Somatic proteome 
ProteomicsCirculating peptidome is strongly altered in COVID-19 patients
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease-19 (COVID-19), an infectious disease characterized by a broad spectrum of symptoms, from mild to severe. Even though the COVID-19 impact on the proteome, metabolome, and lipidome has ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD036020 | Pride
Covid-19  peptidomics  protein degradation  biomarkers  respiratory disease 
ProteomicsNovel insights into Strongyloides stercoralis third stage infective larvae proteome
Background - Strongyloidiasis is a neglected tropical disease affecting an estimated 600 million people, particularly in resource-limited settings. The infection can persist lifelong due to Strongyloides stercoralis peculiar auto-infective cycle. The cumbersome diagnosis and the limited knowledge of...
ORGANISM(S): Strongyloides stercoralis 
2023-03-11 | PXD037243 | Pride
Larvae Feces Strongyloides stercoralis Diagnosis Strongyloidiasis Proteome 
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