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ProteomicsSpheroids treated with and without Drug
MALDI MSI for monitoring of drug response in primary cancer spheroids
ORGANISM(S): Homo sapiens (Human) 
2019-09-03 | PXD013069 | Pride
Spheroids 
TranscriptomicsTranscription profiling of human ovarian cancer cell lines grown as multicellular spheroids and treated with three chemotherapy drugs
Gene expression profiling of ovarian cancer spheroids upon treatment with three chemotherapy drugs
ORGANISM(S): Homo sapiens 
2008-05-06 | E-MEXP-1319 | biostudies-arrayexpress
TranscriptomicsGenomic characterization of ovarian cancer spheroids
Spheroids are 3D multi-cell aggregates formed in non-addherent culture conditions. In ovarian cancer (OC), they serve as a vehicle for cancer cell dissemination in the peritoneal cavity. We investigated genes and networks upregulated in three dimensional (3D) versus two-dimensional (2D) culture cond...
ORGANISM(S): Homo sapiens 
2014-01-03 | E-GEOD-53759 | biostudies-arrayexpress
ProteomicsDiesel particulate matter-induced proteomic changes in three-dimensional spheroids derived from human primary cells of various tissue origins
This study investigated the effects of diesel particulate matter (DPM) on multiple human organs using 3D spheroids derived from eight human primary cell types. To assess the impact of DPM, we exposed these spheroids to varying concentrations of standardized DPM (SRM 2975) and measured their viabilit...
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD056979 | Pride
Three-dimensional (3d) spheroids Mass spectrometry (ms) Diesel particulate matter (dpm) Viability assessment Tandem mass tag (tmt) 
ProteomicsCarnosine effect in scaffold free human dermis spheroids model
Carnosine is an endogenous β-alanyl-L-histidine dipeptide endowed of antioxidant and carbonyl scavenger properties, able to significantly prevent the visible signs of aging and photoaging. To deeply investigate the mechanism of action of carnosine on human skin proteome, a 3D scaf-fold-free spheroid...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD031053 | Pride
Carnosine Spheroids Label free 
TranscriptomicsTranscription profiling of human foreskin fibroblasts grown as multicellular spheroids or as a monolayer
Human foreskin fibroblasts grown as multicellular spheroids or as a monolayer
ORGANISM(S): Homo sapiens 
2009-12-30 | E-MEXP-1226 | biostudies-arrayexpress
ProteomicsHybrid-DIA: Intelligent Data Acquisition for Simultaneous Targeted and Discovery Phosphoproteomics in Single Spheroids
Achieving sufficient coverage of regulatory phosphorylation sites by mass spectrometry (MS)-based phosphoproteomics for signaling pathway reconstitution is challenging when analyzing tiny sample amounts. We present a novel hybrid data-independent acquisition (DIA) strategy (hybrid-DIA) that combines...
ORGANISM(S): Homo sapiens (Human) 
2023-05-18 | PXD038947 | Pride
Phosphoproteomics Targeted Discovery Proteomics Spheroids 
ProteomicsHepatocyte thorns, a novel drug-induced stress response in human and mouse liver spheroids
The in vivo-relevant phenotype of 3D liver spheroids allows for long-term studies of e.g. novel mechanisms of chronic drug-induced liver toxicity. Using this system, we present a novel drug-induced stress response in human and murine hepatocyte spheroids wherein long slender filaments form after chr...
ORGANISM(S): Homo sapiens (Human) 
2022-05-26 | PXD033550 | Pride
Hepatocytes  spheroids  thorns  hepatotoxicity  keratins  3d culture 
GenomicsDenunded HUVEC/HUASMC spheroids vs. HUASMC spheroids
Denunded HUVEC/HUASMC spheroids vs. HUASMC spheroids
PRJNA657248 | ENA
ProteomicsProteomic analysis of paclitaxel or Pelophen B -treated spheroids formed from SKOV3 ovarian carcinoma cells
SKOV3 spheroids were treated with Paclitaxel, Pelophen B or vehicle (DMSO). The spheroids were lysed and proteomic analysis was carried out to compare mechanistically the effects between the two drugs at IC50 concentrations.
ORGANISM(S): Homo sapiens (Human) 
2024-12-04 | PXD049685 | Pride
Cancer Spheroids Taxanes 
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