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UnknownMapping of functional SARS-CoV-2 receptors in human lungs establishes differences in variant binding and SLC1A5 as a viral entry modulator of hACE2.
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S-EPMC9795807 | biostudies-literature
ProteomicsFAM46C is an IFN stimulated gene that restricts lentiviral particle production by modulating autophagy
FAM46C is a multiple myeloma tumour suppressor whose function is only starting to be elucidated. We recently showed that in multiple myeloma cells FAM46C triggers apoptosis by inhibiting autophagy and altering intracellular trafficking and protein secretion. To date, both a physiological characteriz...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD036818 | Pride
Fam46c inhibits lentiviral production 
ProteomicsMapping of Functional SARS-CoV-2 Receptors in Human Lungs Establishes Differences in Variant Binding and SLC1A5 as a Viral Entry Modulator of hACE2
The COVID-19 pandemic is an infectious disease caused by SARS-CoV-2. The first step of SARS-CoV-2 infection is the recognition of angiotensin-converting enzyme 2 (hACE2) receptors by the receptor-binding domain (RBD) of the viral spike (S) glycoprotein. Although the molecular and structural bases of...
ORGANISM(S): Homo sapiens (Human) 
2023-01-09 | PXD038005 | Pride
Spike  super resolution microscopy  ace2 co-factors  rbd  viral binding  viral entry 
TranscriptomicsRNA-seq of Delta47 human myeloma cells expressing either the FNDC3A protein or a Mock control
Total RNAs were isolated from Delta47 human myeloma cells expressing either the FNDC3A protein or a Mock control and sequenced. The Delta47 cell line lacks FNDC3A expression, so the purpose of the experiment was to quantify the differentially-abundant mRNAs in the two cell lines.
ORGANISM(S): Homo sapiens 
2020-10-22 | E-MTAB-8496 | biostudies-arrayexpress
TranscriptomicsRibosome profiling and RNA-seq of in vitro differentiated human CD4+ Th1 cells.
We investigated the translatome of in vitro differentiated human CD4+ Th1 cells.
ORGANISM(S): Homo sapiens 
2020-04-08 | E-MTAB-5961 | biostudies-arrayexpress
TranscriptomicsRNA processing proteins regulate Mec1/ATR activation by promoting generation of RPA-coated ssDNA.
Eukaryotic cells respond to DNA double-strand breaks (DSBs) by activating a checkpoint that depends on the protein kinases Tel1/ATM and Mec1/ATR. Mec1/ATR is activated by RPA-coated single-stranded DNA (ssDNA), which arises upon nucleolytic degradation (resection) of the DSB. Emerging evidences indi...
ORGANISM(S): Saccharomyces cerevisiae 
2014-11-20 | E-GEOD-63444 | biostudies-arrayexpress
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