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MetabolomicsElevated brain manganese induces motor disease by upregulating the kynurenine pathway of tryptophan metabolism
Elevated brain levels of the essential metals manganese (Mn), copper, or iron induce motor disease. However, mechanisms of metal-induced motor disease are unclear and treatments are lacking. Elucidating the mechanisms of Mn-induced motor disease is particularly important because occupational and env...
2025-03-31 | MTBLS975 | MetaboLights
TranscriptomicsMntR(Rv2788): a transcriptional regulator that controls manganese homeostasis in Mycobacterium tuberculosis.
Transcriptional profiling of SirR and manganese regulated expression of genes in Mycobacterium tuberculosis strains comparing high manganese vs. low manganese in Rv (wild type Mycobacterium tuberculosis) and ST70 (mntR mutant strain of Mycobacterium tuberculosis) Two strains each with two conditions...
ORGANISM(S): Mycobacterium tuberculosis 
2015-12-08 | E-GEOD-70812 | biostudies-arrayexpress
MetabolomicsHuntington’s Disease Genotype Suppresses Global Manganese-Responsive Processes
Not available
ORGANISM(S): Mus musculus 
ST001333 | MetabolomicsWorkbench
TranscriptomicsExpanding the Pathways of Manganese Homeostasis: Role of a Small Manganese Chaperone Protein, MntS
Escherichia coli possesses >65 small proteins of <50 amino acids, many of which are uncharacterized. We have identified a new small protein, MntS, involved in manganese homeostasis. Manganese is a critical micronutrient, serving as an enzyme cofactor and protecting against oxidative stress. Yet mang...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2011-12-08 | E-GEOD-25318 | biostudies-arrayexpress
TranscriptomicsRole of Manganese Efflux for Signaling and Pathogenesis in Streptococcus pneumonia
Microarray analysis of Streptococcus pneumoniae TIGR4 transcriptome in response to manganese as the transcriptome changes in response to intracellular manganese accumulation via a mutation in sp1552/mntE a manganese efflux protein. Investigating role of manganese efflux and accumulation in S. pneumo...
ORGANISM(S): Streptococcus pneumoniae TIGR4 
2010-05-22 | E-GEOD-14324 | biostudies-arrayexpress
TranscriptomicsTime course of manganese treatment in LB
The SOS response to DNA damage in bacteria is a well-known component of the complex transcriptional responses to genotoxic environmental stresses such as exposure to reactive oxygen species, alkylating agents, and many of the antibiotics targeting DNA replication. However, bacteria such as Bacillus ...
ORGANISM(S): Bacillus subtilis 
2010-06-12 | E-GEOD-22296 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of SHSY5Y cells exposed to manganese
The trace element manganese is essential for normal development for all the organisms. Overexposure of manganese may leads to multiple neuronal disorders such as Parkinson, manganism. To explore the molecular mechanism of manganese induced neurotoxicity, gene expression profiling was performed on hu...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-70845 | biostudies-arrayexpress
ProteomicsIntestinal response to dietary manganese depletion in Drosophila
Manganese is considered essential for animal growth. Manganese ions serve as cofactors to three mitochondrial enzymes: superoxide dismutase (Sod2), arginase and glutamine synthase. In Drosophila melanogaster, manganese has also been implicated in the formation of ceramide phosphoethanolamine, the in...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2020-02-24 | PXD015543 | Pride
Superoxide dismutase (sod2) White + (w+) 
TranscriptomicsComparison of expression profiles for Agrobacterium tumefaciens wild-type strain C58 grown with or without manganese
The plant pathogen Agrobacterium tumefaciens attaches to and forms biofilms on both biotic and abiotic surfaces. The transition between free-living, planktonic A. tumefaciens and multicellular biofilms is regulated by several well-defined environmental and nutritional inputs, including pH, oxygen te...
ORGANISM(S): Agrobacterium tumefaciens 
2015-07-24 | E-GEOD-71266 | biostudies-arrayexpress
GenomicsMarine sediment manganese-oxidizing enrichment metagenome
Metagenomic sequencing of a marine manganese-oxidizing enrichment culture.
PRJNA1327812 | ENA
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