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MetabolomicsElevated brain manganese induces motor disease by upregulating the kynurenine pathway of tryptophan metabolism
Elevated brain levels of the essential metals manganese (Mn), copper, or iron induce motor disease. However, mechanisms of metal-induced motor disease are unclear and treatments are lacking. Elucidating the mechanisms of Mn-induced motor disease is particularly important because occupational and env...
2025-03-31 | MTBLS975 | MetaboLights
ProteomicsStylosanthes guianensis-LC-MS - Physiological responses and proteomic changes reveal insights into Stylosanthes response to manganese toxicity
Manganese (Mn), an essential element for plants, can be toxic when present in excess. Stylo (Stylosanthes) is a pioneer tropical legume with great potential for Mn tolerance, but its Mn tolerance mechanisms remain poorly understood. In this study, the mechanisms underlying stylo response to Mn toxic...
ORGANISM(S): Stylosanthes guianensis 
2019-05-06 | PXD012379 | Pride
Label-free quantitative proteome Manganese toxicity Stylosanthes 
ProteomicsIntestinal response to dietary manganese depletion in Drosophila
Manganese is considered essential for animal growth. Manganese ions serve as cofactors to three mitochondrial enzymes: superoxide dismutase (Sod2), arginase and glutamine synthase. In Drosophila melanogaster, manganese has also been implicated in the formation of ceramide phosphoethanolamine, the in...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2020-02-24 | PXD015543 | Pride
Superoxide dismutase (sod2) White + (w+) 
TranscriptomicsDecoding the global transcriptomic profile under extreme manganese toxicity
To achieve extreme manganese stress, we used DmntP E. coli strain. We identified the pathways that are altered under manganese stress. Mainly, manganese altered the metabolism of iron in the cell. Therefore, we have shown that iron supplementation mitigates manganese toxicity. Overall, our data expl...
ORGANISM(S): Escherichia coli 
2017-11-01 | GSE88906 | GEO
GenomicsRNA sequencing analysis of genes related to manganese toxicity in Vibrio parahaemolyticus
RNA sequencing analysis of genes related to manganese toxicity in Vibrio parahaemolyticus
PRJNA1212724 | ENA
GenomicsPhysiological and transcriptomic analyses of manganese toxicity response in Stylosanthes leaves
Physiological and transcriptomic analyses of manganese toxicity response in Stylosanthes leaves
PRJNA614929 | ENA
GenomicsRNA-Seq analysis of roots of Stylosanthes guianensis in response to manganese toxicity
RNA-Seq analysis of roots of Stylosanthes guianensis in response to manganese toxicity
PRJNA1206474 | ENA
GenomicsEscherichia coli
Decoding the global transcriptomic profile under extreme manganese toxicity
PRJNA349053 | ENA
UnknownPotential Role of Epigenetic Mechanism in Manganese Induced Neurotoxicity.
Not available
S-EPMC4899583 | biostudies-literature
TranscriptomicsRNA-Seq analysis of roots of Stylosanthes guianensis in response to manganese toxicity
Stylo (Stylosanthes guianensis) is an important tropical legume with superior tolerance to manganese (Mn) toxicity, which severely constrains plant growth especially in tropical acid soils. However, the underlying mechanisms of Mn tolerance in stylo remain largely unknown. SgUBC2, an ubiquitin-conju...
ORGANISM(S): Stylosanthes guianensis 
2026-01-04 | GSE285866 | GEO
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