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TranscriptomicsDefining the microglia transcriptome during disease progression in ALS transgenic mice
Purpose: We purified spinal cord microglia utilizing percoll gradients and magnetic beads, followed by transcriptome profiling (RNA-seq) to define microglia expression profiles against other neural, immune cell-types. We next observed how the microglial transcriptomes change during activation in the...
ORGANISM(S): Mus musculus 
2013-07-15 | E-GEOD-43366 | biostudies-arrayexpress
TranscriptomicsPhenotypically concordant and discordant monozygotic twins display different DNA copy number variation profiles (SNP)
The exploration of copy number variation (CNV), notably of somatic cells, is an understudied aspect of genome biology. Any differences in the genetic make-up between twins derived from the same zygote represent an extreme example of somatic variation. We studied 19 pairs of monozygotic twins with ei...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-9608 | biostudies-arrayexpress
TranscriptomicsAn intricate interplay between astrocytes and motor neurons in ALS
Amyotrophic Lateral Sclerosis (ALS) results from the selective and progressive degeneration of motor neurons. Although the underlying disease mechanisms remain unknown, glial cells have been implicated in ALS disease progression. Here we examine the effects of glial cell/motor neuron interactions on...
ORGANISM(S): Mus musculus 
2013-02-11 | E-GEOD-43879 | biostudies-arrayexpress
TranscriptomicsCoordinated regulation of neuronal mRNA steady-state levels through developmentally controlled intron retention
Differentiated cells acquire unique structural and functional traits through coordinated expression of lineage-specific genes. An extensive battery of genes encoding components of the synaptic transmission machinery and specialized cytoskeletal proteins is activated during neurogenesis, but the unde...
ORGANISM(S): Mus musculus 
2012-07-12 | E-GEOD-37933 | biostudies-arrayexpress
UnknownHistone and DNA Modifications as Regulators of Neuronal Development and Function.
Not available
S-EPMC4930923 | biostudies-literature
UnknownExpressionPlot: a web-based framework for analysis of RNA-Seq and microarray gene expression data.
Not available
S-EPMC3218831 | biostudies-literature
UnknownNegative regulation of interferon-β gene expression during acute and persistent virus infections.
Not available
S-EPMC3108996 | biostudies-literature
UnknownLarge exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.
Not available
S-EPMC16203 | biostudies-literature
TranscriptomicsGenomic profiles vary with race and subtype in young African American and European American breast cancer (SNP)
In the United States, African-American (AA) women are more likely to develop early-onset breast cancer and have historically poorer outcomes due to this disease compared to European-American (EA) women. Here, we analyzed genomic profiles of breast tumors from young women (<50 years old), matched by ...
ORGANISM(S): Homo sapiens 
2013-01-29 | E-GEOD-26232 | biostudies-arrayexpress
UnknownComparative DNA sequence analysis of mouse and human protocadherin gene clusters.
Not available
S-EPMC311048 | biostudies-literature
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