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Wiskott-Aldrich syndrome (WAS) predisposes patients to leukemia and lymphoma. WAS is caused by mutations in the protein WASP which impair its interaction with the WIPF1 protein. Here, we aim to identify a module of WIPF1-coexpressed genes and to assess its use as a prognostic signature for colorecta...
ORGANISM(S): Homo sapiens 
Activation of protein kinase C epsilon (PKCε) in the liver has been widely associated with hepatic insulin resistance. PKCε is proposed to inhibit insulin signalling through phosphorylation of the insulin receptor. We have tested this directly by breeding PKCε floxed mice with mice expressing Cre re...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-04 | PXD010212 | Pride
To systematically explore the dynamics of the synaptic proteome upon neuronal stimulation we employed a simple model system which is based on isolated synaptoeurosomes (SN). Synaptoneurosomes are preparations freshly obtained from the brain and enriched in synapses, containing both pre and postsyna...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-12 | PXD012707 | Pride
To systematically explore the dynamics of the synaptic proteome upon neuronal stimulation we employed a simple model system which is based on isolated synaptoeurosomes (SN). Synaptoneurosomes are preparations freshly obtained from the brain and enriched in synapses, containing both pre and postsyna...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-12 | PXD012746 | Pride
Myogenesis is governed by signalling networks whose regulations are tightly controlled in a time-dependent manner. While different protein kinases have been identified to regulate various aspects of myogenesis, knowledge on the global signalling networks and their downstream substrates during myogen...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-31 | PXD028713 | Pride
Ten healthy male participants were recruited and successfully completed all preliminary testing and the two exercise bouts (Figure 1A). This randomized crossover design permitted signaling responses to workload- and duration-matched HIIT and MICT exercise to be mapped and interrogated within the sam...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD053295 | Pride
OBJECTIVE: To assess the safety and efficacy as well as determination of the molecular mechanism of action of topical allogeneic ADSC therapy in the treatment of ulcers in patients with neuropathic diabetic foot. RESEARCH DESIGN AND METHODS: We examined a total of 57 patients with neuropathic diab...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD032099 | Pride
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ORGANISM(S): Homo sapiens 
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