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GenomicsChIP-seq of RNA polymerase II from WI-38hTERT/sh3-H2AFJ and WI-38hTERT/sh-NT fibroblasts in proliferation and etoposide-induced senescence.
The intent of the experiment was to compare RNA polymerase II occupancy on the chromatin of WI-38hTERT/sh3-H2AFJ and WI-38hTERT/sh-NT fibroblasts in proliferation and etoposide-induced senescence.
ORGANISM(S): Homo sapiens 
2020-11-02 | E-MTAB-9717 | biostudies-arrayexpress
GenomicsChIP-seq of H3-K4me3 from WI-38hTERT/sh3-H2AFJ and WI-38hTERT/sh-NT fibroblasts in proliferation and etoposide-induced senescence.
The intent of the experiment was to compare H3-K4me3 peaks on the chromatin of WI-38hTERT/sh3-H2AFJ and WI-38hTERT/sh-NT fibroblasts in proliferation and etoposide-induced senescence.
ORGANISM(S): Homo sapiens 
2020-11-02 | E-MTAB-9718 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis by Illumina microarrays of the effect of overexpressing H2A.J mutants, or WT H2A.J or canonical H2A, on the transcriptome of WI-38hTERT fibroblasts
The intent of the experiment was to test the effect of overexpressing H2A.J-V11A, H2AJ-S123E, H2A.J-S123A, and H2A.J-CterH2A mutants, as well as WT-H2A.J and canonical H2A-type1, on the transcriptome of WI-38hTERT fibroblasts. pTRIPz based lentiviral constructs placing these coding sequences under t...
ORGANISM(S): Homo sapiens 
2020-11-01 | E-MTAB-9706 | biostudies-arrayexpress
TranscriptomicsRNA-seq of small RNAs in WI-38hTERT/sh3-H2AFJ and WI-38hTERT/sh-NT fibroblasts in proliferation and etoposide-induced senescence
The intent of the experiment was to identify differentially expressed micro-RNAs comparing WI-38hTERT/sh3-H2AFJ and WI-38hTERT/sh-NT fibroblasts in proliferation and etoposide-induced senescence.
ORGANISM(S): Homo sapiens 
2020-11-02 | E-MTAB-9710 | biostudies-arrayexpress
TranscriptomicsRNA-seq of rRNA-depleted total RNAs in WI-38hTERT/sh3-H2AFJ and WI-38hTERT/sh-NT fibroblasts in proliferation and etoposide-induced senescence.
The intent of the experiment was to identify differentially expressed RNAs comparing WI-38hTERT/sh3-H2AFJ and WI-38hTERT/sh-NT fibroblasts in proliferation and etoposide-induced senescence.
ORGANISM(S): Homo sapiens 
2020-11-02 | E-MTAB-9714 | biostudies-arrayexpress
TranscriptomicsRNA-seq of H2afj-ko and isogenic WT C57/Bl6-N mouse embryonic fibroblasts in proliferation and after etoposide-induced senescence.
Determine the effect of knocking out the H2afj gene on the transcriptome of MEFs induced into senescence with etoposide. MEFs were produced from individual H2A.J-ko or isogenic WT C57BL/6-N embryos. 3 different female WT and H2A.J-ko MEFs were used for the transcriptome analyses. MEFs were cultivate...
ORGANISM(S): Mus musculus 
2020-11-02 | E-MTAB-9704 | biostudies-arrayexpress
TranscriptomicsHP1, H3-K27me3, and H3-K9me3 Cut & Tag of Het (Cbx1+/+, Cbx3+/+, Cbx5+/-) and TKO (Cbx1-/-, Cbx3-/-, Cbx5-/-) bipotential mouse embryonic liver (BMEL) cells
Cut & Tag was used to localize the 3 mouse HP1 proteins (Cbx1,Cbx3,Cbx5) to the genome of BMEL (bipotential mouse embryonic liver) cells. Het BMEL cells are Cbx1+/+, Cbx3+/+, Cbx5+/- HP1-TKO (triple knock-out cells) are Cbx1-/-, Cbx3-/-, Cbx5-/-. The HP1_TKO cells were used to verify the specificity...
ORGANISM(S): Mus musculus 
2025-06-14 | E-MTAB-15189 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human breast cancer cell line T47D and 2 different T47D_H2A.J-KO cells lines treated with tamoxifen and untreated controls
The experiment is intended to test the effect of the Cripsr/Cas9 deletion of the H2AFJ gene encoding the histone variant H2A.J on the transcriptome of luminal breast cancer T47D cells in conditions of proliferation, and after proliferative arrest induced by treating the cells with 5 µm tamoxifen for...
ORGANISM(S): Homo sapiens 
2021-09-20 | E-MTAB-10861 | biostudies-arrayexpress
ProteomicsIn-depth proteomic analyses of Haliotis laevigata (greenlip abalone) nacre and prismatic organic shell matrix
Background: The shells of various Haliotis species have served as models of invertebrate biomineralization and physical shell properties for more than 20 years. A focus of this research has been the nacreous inner layer of the shell with its conspicuous arrangement of aragonite platelets, resembling...
ORGANISM(S): Haliotis laevigata 
2018-06-18 | PXD009567 | Pride
Nacre Proteome Biomineralization Mantle transcriptome Shell organic matrix Prismatic layer 
TranscriptomicsHIF2A(EPAS1) Genome-Wide Localization in MRC5 Human Fibroblasts by Cut & Tag
HIF2A(EPAS1) geenome_wide localization by Cut & Tag in MRC5 human fibroblasts ectopically expressing HIF2A in the pBabe vector, and in control MRC5 human fibroblasts containing only the pBabe vector. 2 biological replicates were done for the MRC5-HIF2A cells. Cut & Tag with an anti-H3-K27me3 Ab was ...
ORGANISM(S): Homo sapiens 
2025-01-17 | E-MTAB-13732 | biostudies-arrayexpress
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