Sort   by:  
 Page size 
Unknown<i>De novo</i> design of drug-binding proteins with predictable binding energy and specificity.
Not available
S-EPMC10769398 | biostudies-literature
UnknownTargeting Gli transcription activation by small molecule suppresses tumor growth.
Not available
S-EPMC3947751 | biostudies-literature
UnknownDe novo design of drug-binding proteins with predictable binding energy and specificity.
Not available
S-EPMC11290694 | biostudies-literature
ProteomicsBudding yeast relies on qualitative G1 cyclin specificity to couple cell cycle progression with morphogenetic development
Two models have been put forward for cyclin-dependent kinase (Cdk) control of the cell cycle. In the qualitative model, cell cycle events are ordered by distinct substrate specificities associated with successive waves of G1, S and mitotic cyclins. Alternatively, the gradual quantitative rise of Cdk...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-08-23 | PXD022757 | Pride
Lc-ms/ms Tmt Cdk Yeast Cyclin Cell cycle Phosphoproteomics Cyclin-dependent kinase 
UnknownCross-neutralization and viral fitness of SARS-CoV-2 Omicron sublineages.
Not available
S-EPMC9848280 | biostudies-literature
UnknownExome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway.
Not available
S-EPMC4589486 | biostudies-literature
UnknownAssessing the impact of day programs on individuals living with dementia and their family/friend caregivers (AIDA-DemCare): protocol of a prospective cohort study combined with a qualitative evaluation.
Not available
S-EPMC12363022 | biostudies-literature
MetabolomicsNeuronal Hyperactivity due to Loss of Inhibitory Tone in APOE4 Mice Lacking Alzheimer’s Disease-like Pathology
Metabolite profiling was performed on metabolites extracted from the entorhinal cortex and primary visual cortex of 14-15 month old APOE3/3, APOE3/4 and APOE4/4 mice. Metabolites were run on a TOF Mass Spectrometer using an ANP column. Initial analysis was done in an untargeted manner, and processin...
2017-09-05 | MTBLS530 | MetaboLights
TranscriptomicsA novel recurrent mutation in MITF predisposes to familial and sporadic melanoma
We identified a novel germline mutation of the microphthalmia-associated transcription factor (MITF - E318K). This mutation was found to be present in numerous melanoma families, as well as the general population, where its association with melanoma has a significant effect. We determined the effe...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-31269 | biostudies-arrayexpress
GenomicsA novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

We conducted whole-genome sequencing of probands from several melanoma families, identifying one individual carrying a novel germline variant (c.G1075A, NM_000248.3; p.E318K, NP_000239.1; rs149617956) in the melanoma lineage-specific oncogene MITF. While the variant cosegregated with melanoma in ...

phs000419.v1.p1 | EGA
Sort   by:  
 Page size