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UnknownRandomized controlled trial of a video decision support tool for cardiopulmonary resuscitation decision making in advanced cancer.
Not available
S-EPMC4090424 | biostudies-literature
TranscriptomicsTranscription profiling of transition from normal intestinal epithelia to adenomas and carcinomas in the APC(Min/+) mice to identify differentially expressed transcripts.
Transcriptional Profiling of the Transition from Normal Intestinal Epithelia to Adenomas and Carcinomas in the APC(Min/+) Mouse. Samples used in analysis:; * GSM6191-GSM6196 (WT): Ilea epithelial cells from C57/BL6 wild-type samples; * GSM6197-GSM6201 (Adenoma): Epithelial cells from crypts of adeno...
ORGANISM(S): Mus musculus 
2007-11-06 | E-GEOD-422 | biostudies-arrayexpress
ProteomicsProfiling tissue-specific modulation of gene expression in response to insulin signalling in Drosophila
We investigated tissue-specific regulation of gene expression in a long lived Drosophila IIS mutant (dilp2-3,5) compared to its control (wDah). As in the majority of Drosophila laboratory strains, the endosymbiont Wolbachia was present; in the absence of Wolbachia, life extension through dilp2-3,5 i...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-04-21 | PXD011589 | Pride
Drosophila tissue-specific insulin longevity lifespan aging shotgun 
ProteomicsA proteomic atlas of insulin signaling reveals tissue-specific mechanisms of longevity-assurance
Lowered activity of the insulin/IGF signaling (IIS) network can ameliorate the effects of ageing in model organisms and, possibly, humans. Remodelling of the RNA transcriptome of long-lived IIS mutants has been extensively documented, but is only weakly predictive of consequent changes in protein ex...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2017-09-13 | PXD006225 | Pride
Q exactive Insulin signaling Tissue specific Shotgun Drosophila melanogaster 
ProteomicsFunctional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants
Human longevity, coupled to compression of age-related disease, is heritable. However, few common genetic variants have been linked to longevity, suggesting that rare, family-specific variants may also play a role. We therefore investigated whole-genome sequencing data of long-lived families from th...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-16 | PXD063190 | Pride
Longevity Rare variants Functional characterisation Ageing Genetics Mapk/erk signalling pathway 
UnknownColorectal resection in emergency general surgery: An EAST multicenter trial.
Not available
S-EPMC7957828 | biostudies-literature
UnknownSacubitril/Valsartan in Pediatric Heart Failure (PANORAMA-HF): A Randomized, Multicenter, Double-Blind Trial.
Not available
S-EPMC11593999 | biostudies-literature
MetabolomicsPlasma Lipidomics Identifies Anticedent Memory Impairment in Older Adults
Alzheimer's disease causes a progressive dementia that currently affects over 35 million individuals worldwide and is expected to affect 115 million by 2050 (ref. 1). There are no cures or disease-modifying therapies, and this may be due to our inability to detect the disease before it has progresse...
2014-03-09 | MTBLS72 | MetaboLights
GenomicsA novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

We conducted whole-genome sequencing of probands from several melanoma families, identifying one individual carrying a novel germline variant (c.G1075A, NM_000248.3; p.E318K, NP_000239.1; rs149617956) in the melanoma lineage-specific oncogene MITF. While the variant cosegregated with melanoma in ...

phs000419.v1.p1 | EGA
TranscriptomicsA novel recurrent mutation in MITF predisposes to familial and sporadic melanoma
We identified a novel germline mutation of the microphthalmia-associated transcription factor (MITF - E318K). This mutation was found to be present in numerous melanoma families, as well as the general population, where its association with melanoma has a significant effect. We determined the effe...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-31269 | biostudies-arrayexpress
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