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TranscriptomicsExpression data from Brakeless mutant Drosophila embryos
The Brakeless protein performs many important functions during Drosophila development, but how it controls gene expression is not understood. We previously showed that Brakeless can function as a transcriptional co-repressor. Here, we report transcriptional profiling of brakeless mutant embryos to i...
ORGANISM(S): Drosophila melanogaster 
2015-08-24 | E-GEOD-60048 | biostudies-arrayexpress
GenomicsDorsal dependent CBP binding on a genome wide scale
We find a high concordance between the binding of the Drosophila transcription factor Dorsal and the co-activator CBP during early embryogenesis. This relationship was furter examined by comparing CBP distribution in Drosophila embryos derived from wt and mutant flies lacking intranuclear Dorsal (gd...
ORGANISM(S): Drosophila melanogaster 
2012-06-28 | E-GEOD-34221 | biostudies-arrayexpress
GenomicsCBP occupancy in Drosophila S2 cells
CREB-binding protein (CBP, also known as nejire) is a transcriptional co-activator that is conserved in metazoans. We have generated CBP ChIP-seq data from Drosophila S2 cells and compared it to modENCODE data. This shows that CBP is bound at genomic sites with a wide range of functions. As expected...
ORGANISM(S): Drosophila melanogaster 
2015-11-06 | E-GEOD-64464 | biostudies-arrayexpress
TranscriptomicsCBP regulates promoter-proximal RNA polymerase II
Transcription activation involves RNA polymerase II (Pol II) recruitment and release from the promoter into productive elongation, but how specific chromatin regulators control these steps is not fully understood. Here we identify a novel activity of the co-regulator and histone acetyltransferase p3...
ORGANISM(S): Drosophila melanogaster 
2016-08-01 | E-GEOD-81649 | biostudies-arrayexpress
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