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TranscriptomicsDissecting the signalling pathways underlying cellular senescence
Cellular senescence is a program of irreversible cell cycle arrest that normal cells undergo in response to progressive shortening of telomeres, changes in telomeric structure, oncogene activation or oxidative stress. The underlying signalling pathways, potentially of major clinicopathological rele...
ORGANISM(S): Homo sapiens 
2011-01-21 | E-GEOD-24810 | biostudies-arrayexpress
TranscriptomicsHMF3A_with_3Dwt
HMF3A cells, created from adult human mammary fibroblasts by immortalisation with a thermolabile SV40 large T antigen and the catalytic sub-unit of human telomerase, undergo co-ordinated induction of cellular senescence upon inactivation of T antigen. HMF3A cells cease proliferating by 4 days at 39Â...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-688 | biostudies-arrayexpress
TranscriptomicsPrim_Fibs
To determine changes in gene expression in primary fibroblasts undergoing replicative senescence, a direct comparison between early passage proliferating cells and senescent cells was performed. Frozen stocks of the primary fibroblasts (HMF3) from which the lines HMF3A and HMF3Dwt were derived (O'Ha...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-687 | biostudies-arrayexpress
TranscriptomicsHMF3A_RNAi
HMF3A cells, created from adult human mammary fibroblasts by immortalisation with a thermolabile SV40 large T antigen and the catalytic sub-unit of human telomerase, undergo co-ordinated induction of cellular senescence upon inactivation of T antigen. The pSUPER-retro vector system (Brummelkamp, 200...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-690 | biostudies-arrayexpress
TranscriptomicsDiff_cell_shift
Immortalised lines created from different cell types from the human breast were induced to undergo senesecence by inactivation of the immortalising LT antigen.
ORGANISM(S): Homo sapiens 
2010-06-10 | E-GEOD-2427 | biostudies-arrayexpress
TranscriptomicsGSEp53_v_Con
HMF3A cells, created from adult human mammary fibroblasts by immortalisation with a thermolabile SV40 large T antigen and the catalytic sub-unit of human telomerase, undergo co-ordinated induction of cellular senescence upon inactivation of T antigen. Given the importance of p53, we sought to determ...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-689 | biostudies-arrayexpress
UnknownMetformin for patients with metastatic prostate cancer starting androgen deprivation therapy: a randomised phase 3 trial of the STAMPEDE platform protocol.
Not available
S-EPMC12303861 | biostudies-literature
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