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TranscriptomicsGermfree C57BL/6J mice are resistant to high fat diet-induced insulin resistance and have altered cholesterol metabolism
Germfree (GF) mice have been used as a model to study the contribution of the intestinal microbiota to metabolic energy balance of the host. Despite a wealth of knowledge accumulated since the 1940’s, the response of GF mice to a high fat diet is largely unknown. In the present study, we compared th...
ORGANISM(S): Mus musculus 
2010-08-20 | E-GEOD-19038 | biostudies-arrayexpress
TranscriptomicsConsequences of exchanging carbohydrates for proteins in the cholesterol metabolism of mice fed a high-fat diet
Dietary proteins have profound effects on lipid metabolism but the mechanism remains to be elucidated. In the present study, we examined the temporal impact of dietary proteins in isoenergetic high fat diets on lipid metabolism of C57BL/6J mice. Mice were first fed a low protein (P) to carbohydrate ...
ORGANISM(S): Mus musculus 
2012-12-19 | E-GEOD-20260 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of muscle gene expression in response to an intense cycling exercise. Effect of two protein-leucine enriched diets
Protein-leucine supplement ingestion following strenuous endurance exercise accentuates skeletal-muscle protein synthesis and adaptive molecular responses, but the underlying transcriptome is uncharacterized. In a randomized single-blind triple-crossover design, 12 trained men completed 100 min of h...
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-44818 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat small intestine and colon samples treated with amoxicillin
Whole tissues corresponding to the proximal and distal small intestine and to the colon were dissected from each rat, washed with ice-cold saline solution and immediately frozen in liquid nitrogen. Rats were either control or treated with Amoxicillin (100mg/kg/day). Small intestine was divided in tw...
ORGANISM(S): Rattus norvegicus 
2007-10-08 | E-GEOD-2354 | biostudies-arrayexpress
TranscriptomicsTranscriptome and translational signaling following endurance exercise in trained skeletal muscle: impact of dietary protein
Impact of protein ingestion following 1 h intense cycling on the induced transcriptome and signaling in biopsy samples from endurance-trained men, relative to isocaloric control Single blind, randomized, crossover design comprising two experimental blocks. During the blocks, exercise and diet were c...
ORGANISM(S): Homo sapiens 
2011-11-21 | E-GEOD-27285 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of colon, ileum, jejunum and liver from wild type and hepatic cytochrome P-450 reductase null mice treated with quercetin to identify differential transcriptional responses to quercetin.
This SuperSeries is composed of the following subset Series: GSE4256: Colon transcriptional response to quercetin in WT and POR-null mice; GSE4257: Ileum transcriptional response to quercetin in WT and POR-null mice; GSE4258: Jejunum transcriptional response to quercetin in WT and POR-null mice; GSE...
ORGANISM(S): Mus musculus 
2007-11-06 | E-GEOD-4262 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human IFN-Gamma treated keratinocytes
An experiment comparing control versus IFN-g treated skin cells (one design factor on two levels). To evaluate the biological and the experimental variability, the following experimental design was planned as shown in Figure 1: "Control" and "IFN-g stimulated" keratinocytes were cultured in triplica...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-1132 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Hsd:ICR(CD-1) mouse intestines to study regional variations in ABC transporter expression along the mouse intestinal tract.
8 week-old male Hsd:ICR(CD-1) mice were fed ad libitum a standard chow (Harlan Teklad diet 2018S) and housed in groups of five. Animals were then divided into 3 pools (n=10) and sacrificed. The small intestine was extracted and divided into three sections, where the first 2-3 cm after the stomach co...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-849 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse colon response to quercetin in WT and POR-null animals
Using mice deficient in hepatic cytochrome-P450 oxidoreductase (POR), which disables the liver cytochrome P450 system, the metabolism and biological response of the anti-carcinogenic flavonoid, quercetin, was examined. Profiling circulating metabolites revealed similar profiles over 72 h in wild typ...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4256 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver response to quercetin in WT and POR-null mice
Using mice deficient in hepatic cytochrome-P450 oxidoreductase (POR), which disables the liver cytochrome P450 system, the metabolism and biological response of the anti-carcinogenic flavonoid, quercetin, was examined. Profiling circulating metabolites revealed similar profiles over 72 h in wild typ...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4259 | biostudies-arrayexpress
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