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ProteomicsDigestion of a variety of synthetic peptides by proteasomes
Proteasomes are large multi-subunit enzymes that act as the main producers of antigenic peptides presented at the cell surface to CD8+ T cells. They can simply cut proteins or recombine their fragments thereby generating novel sequences, i.e. spliced peptides via a process called proteasome-catalyse...
ORGANISM(S): Homo sapiens (Human) 
2020-04-14 | PXD016782 | Pride
Synthetic peptides Proteasome Digestion Lc-ms/ms 
ProteomicsKRAS G12V digestion by 20S proteasome
KRAS is a well known tumor associated antigen. It’s a GTPase that functions as molecular switch in regulatory pathways responsible for proliferation and survival. It’s frequently mutated in a variety of cancers. One of the possible driver mutations is G12V substitution, which impairs KRAS GTPase act...
ORGANISM(S): Homo sapiens (Human) 
2019-10-24 | PXD015580 | Pride
Proteasome Cancer Kras Digestion Lc-ms/ms 
UnknownMolecular requirements for PLK1 activation by T-loop phosphorylation
Not available
S-SCDT-10_1038-S44318-025-00681-0 | biostudies-other
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