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MetabolomicsMyeloid PFKFB3-mediated glycolysis promotes kidney fibrosis
Excessive renal fibrosis is a common pathology in progressive chronic kidney diseases. Inflammatory injury and aberrant repair processes contribute to the development of kidney fibrosis. Myeloid cells, particularly monocytes/macrophages, play a crucial role in kidney fibrosis by releasing their proi...
2024-03-12 | MTBLS8278 | MetaboLights
UnknownRecent advances on phylogenomics of gymnosperms and a new classification.
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S-EPMC9363647 | biostudies-literature
UnknownAutoantibody profiling of autism spectrum disorder patients with monoamine oxidase a deficiency.
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S-EPMC12226381 | biostudies-literature
UnknownDynamic Variation of Amino Acid Contents and Identification of Sterols in Xinyang Mao Jian Green Tea.
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S-EPMC9182030 | biostudies-literature
UnknownHost factor RBM25 promotes HBV replication through Yin Yang 1-mediated cccDNA transcription.
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S-EPMC12282445 | biostudies-literature
UnknownRobot-assisted radical cystectomy with the clinical application of "Y-shaped" end-to-side ureteral anastomosis in elderly and obese patients.
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S-EPMC11924684 | biostudies-literature
UnknownEstablishment of a Simple and Rapid Nucleic Acid Detection Method for Hookworm Identification.
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S-EPMC10142964 | biostudies-literature
UnknownEnhancement and analysis of Anthracene degradation by Tween 80 in LMS-HOBt.
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S-EPMC8222252 | biostudies-literature
ProteomicsSequential Glycosylations at the Multibasic Cleavage Site of SARS-CoV-2 Spike Protein Regulate Viral Activation, Assembly, and Infection
The multibasic furin cleavage site at the S1/S2 boundary of the spike protein (S protein) is a hallmark of SARS-CoV-2 and plays an crucial role in viral infection. O-glycosylation near the furin site catalyzed by host cell glycosyltransferases can theoretically hinder spike protein processing and im...
ORGANISM(S): Homo sapiens (Human) 
2024-03-21 | PXD049110 | Pride
Sars-cov-2 O-glycosylation Galnac-t7 Viral assembly 
MetabolomicsPFKFB3-mediated glycolysis boosts fibroblast activation and subsequent kidney fibrosis

Renal fibrosis, a hallmark of chronic kidney diseases, is driven by the activation of renal fibroblasts. Recent studies have highlighted the role of glycolysis in this process. Nevertheless, one critical glycolytic activator, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), remain...

2024-03-12 | MTBLS8281 | MetaboLights
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