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ProteomicsBioID proximity labelling of MAP4K4 interactors in HEK-293T cells
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) is Ser/Thr protein kinase highly expressed in medulloblastoma (MB) patient samples which promotes cell migration and invasiveness downstream of growth factor receptors. Although MAP4K4 implication in the control of the membrane protrus...
ORGANISM(S): Homo sapiens (Human) 
2022-08-04 | PXD031863 | Pride
Bioid Map4k4 
ProteomicsBioID proximity labelling of MAP4K4 interactors in DAOY medulloblastoma cells
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) is Ser/Thr protein kinase highly expressed in medulloblastoma (MB) patient samples which promotes cell migration and invasiveness downstream of growth factor receptors. Although MAP4K4 implication in the control of the membrane protrus...
ORGANISM(S): Homo sapiens (Human) 
2022-08-04 | PXD031870 | Pride
Bioid Medulloblastoma Map4k4 
TranscriptomicsExpression data from serum-starved human umbilical vein endothelial cells that have been treated with scrambled (scr) or Map4k4 siRNA to knock down genes of interest 48 hours prior to harvest
We identified that knocking down Map4k4 in endothelial cells affected genes associated with the cell cycle, mitosis, and inflammatory genes. We used microarrays to identify genes of interest that are differentially expressed after the addition of scrambled or Map4k4 siRNA. HUVECs were treated with s...
ORGANISM(S): Homo sapiens 
2016-04-01 | E-GEOD-78107 | biostudies-arrayexpress
GenomicsPhosphatase MAP4K4 regulates neutrophil development through the apoptosis pathway
Phosphatase MAP4K4 regulates neutrophil development through the apoptosis pathway
PRJNA1157446 | ENA
TranscriptomicsPhosphatase MAP4K4 regulates neutrophil development through the apoptosis pathway
The role of MAP4K4 in the development of neutrophils remains largely unexplored. We utilized single cell sequencing (scRNA-seq) technology to elucidate the impact of Map4k4 deficiency on neutrophil maturation within mouse bone marrow. Through the application of scRNA-seq, we characterized the transc...
ORGANISM(S): Mus musculus 
2025-02-12 | GSE276482 | GEO
GenomicsA novel pharmacological inhibitor of MAP4K4 activity protect against preclinical model of metabolic dysfunction-associated steatohepatitis
A novel pharmacological inhibitor of MAP4K4 activity protect against preclinical model of metabolic dysfunction-associated steatohepatitis
PRJNA1329322 | ENA
UnknownOvercoming radioresistance of breast cancer cells with MAP4K4 inhibitors.
Not available
S-EPMC10978830 | biostudies-literature
ProteomicsA classic famous prescription alleviates inflammation in CUMS model mice via modulating MYDGF/MAP4K4/NF-κB signaling pathway, verified through UPLC-HRMS and proteomics analysis
Major depressive disorder (MDD) has caused a heavy burden on society and affected over 350 million patients worldwide currently. However, there have been 30-50% MDD patients with non-response to antidepressants. Chronic unpredictable mild stress (CUMS) has been considered as a critical trigger facto...
ORGANISM(S): Mus Sp. 
PXD053391 |
UnknownMAP4K4/JNK Signaling Pathway Stimulates Proliferation and Suppresses Apoptosis of Human Spermatogonial Stem Cells and Lower Level of MAP4K4 Is Associated with Male Infertility.
Not available
S-EPMC9739186 | biostudies-literature
UnknownCooperation of Striatin 3 and MAP4K4 promotes growth and tissue invasion.
Not available
S-EPMC9360036 | biostudies-literature
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