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ProteomicsMass spectrometry-based proteomics reveals potential roles of NEK9 and MAP2K4 in resistance to PI3K inhibitors in triple negative breast cancer

Filip Mundt, Sandeep Rajput, Shunqiang Li, Kelly Ruggles, Arshag D. Mooradian, Philipp Mertins, Michael A. Gillette, Karsten Krug, et al., Cancer Res. 2018 May 15;78(10):2732-2746. doi: 10.1158/0008-5472.CAN-17-1990.

Activation of phosphoinositide 3-kinase (PI3K) signaling is frequently obs...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-10-19 | MSV000083050 | MassIVE
ProteomicsCold Atmospheric Plasma Jet Activated Medium Promotes Wound Healing through CK2-mediated ERK and AKT signaling pathways
In this study, we aimed to explore the molecular mechanisms of wound healing affected by CAPJ using the parallel MS-based proteome and phosphoproteome. The keratinocyte, HaCaT, was used as cell mode to treat CAPJ indirectly by employing plasma activated medium (PAM) which was culture medium explored...
ORGANISM(S): Homo Sapiens (human) 
2025-02-22 | PXD050065 | JPOST Repository
ModelsPappalardo2016 - PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer
Pappalardo2016 - PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer This model is described in the article: Computational Modeling of PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer. Pappalardo F, Russo G, Candido S, P...
2024-09-02 | BIOMD0000000666 | BioModels
ProteomicsDissection of IL-2 and IL-15 signaling pathways
The aim of this study was to compare the signaling cascades initiated by the two closely related cytokines IL-2 and IL-15. Considering the relevance of protein tyrosine phosphorylation in signal transduction, in order to quantify changes in protein phosphorylation in response to IL-2 and IL-15, we c...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080767 | MassIVE
TranscriptomicsPten loss and RAS/MAPK activation cooperate to promote EMT and prostate cancer metastasis initiated from stem/progenitor cells
PTEN loss or PI3K/AKT signaling pathway activation correlates with human prostate cancer progression and metastasis. However, in preclinical murine models, deletion of Pten alone fails to mimic the significant metastatic burden that frequently accompanies the end stage of human disease. To identify...
ORGANISM(S): Mus musculus 
2012-02-28 | E-GEOD-34839 | biostudies-arrayexpress
ModelsHeberleRazquinNavas2019 - The PI3K and MAPK/p38 pathways control stress granuleassembly in a hierarchical manner model 3
All cells and organisms exhibit stress-coping mechanisms toensure survival. Cytoplasmic protein-RNA assemblies termedstress granules are increasingly recognized to promote cellularsurvival under stress. Thus, they might represent tumor vul-nerabilities that are currently poorly explored. The transla...
2024-09-02 | BIOMD0000000907 | BioModels
ModelsRouhimoghadam2018 - GPR30/PI3K/MAPK/STAT signaling pathway in normal and cancer cells
In the current study, we aimed to simulate the GPR30/PI3K/MAPK/STAT signaling pathway in normal and cancer cells by the use of ordinary differential equation modeling. In addition, we planned to show that MAPK activation pattern is different between normal and cancer models.
2020-03-16 | MODEL2002250001 | BioModels
ModelsRouhimoghadam2018 - GPR30/PI3K/MAPK/STAT signaling pathway in normal and cancer cells
In the current study, we aimed to simulate the GPR30/PI3K/MAPK/STAT signaling pathway in normal and cancer cells by the use of ordinary differential equation modeling. In addition, we planned to show that MAPK activation pattern is different between normal and cancer models.
2018-07-12 | MODEL1807040001 | BioModels
ModelsHeberleRazquinNavas2019 - The PI3K and MAPK/p38 pathways control stress granuleassembly in a hierarchical manner model 2
All cells and organisms exhibit stress-coping mechanisms to ensure survival. Cytoplasmic protein-RNA assemblies termed stress granules are increasingly recognized to promote cellular survival under stress. Thus, they might represent tumor vulnerabilities that are currently poorly explored. The trans...
2024-09-26 | MODEL2001030002 | BioModels
TranscriptomicsTranscriptional signature of wounded keratinocytes reveals selective roles for ERK1/2, P38 and PI3K signalling pathways
Covering denuded dermal surface after injury requires migration, proliferation and differentiation of skin keratinocytes. To clarify the major traits controlling these intermingled biological events, we surveyed the genomic modifications occurring during the course of a scratch closure of cultured h...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-6820 | biostudies-arrayexpress
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