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TranscriptomicsInteraction between endothelium and chronic lymphocytic leukemia B-cells rescues from apoptosis and modulates gene expression profile of leukemic cells
Chronic lymphocytic leukemic B cells (CLL) reside in close contact with activated endothelial cells (EC) in infiltrated tissues. Here, we investigated the interactions between EC and CLL cells, highlighting molecular networks involved in this cellular crosstalk. We co-cultured purified CLL cells on ...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-28787 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human untreated B-cell chronic lymphocytic leukemia
B-cell chronic lymphocytic leukemia (B-CLL) shows an incredibly high heterogeneity in the clinical course, spanning from rapidly aggressive to completely indolent behaviour. In order to identify the correspondent gene expression variability, we investigated 29 cases of untreated B-CLL using microarr...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-4207 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of monocytes derived from chronic lymphocytic leukemia patients and normal controls
We collected monocytes from peripheral blood of 5 chronic lymphocytic leukemia (CLL) patients and 5 healthy donors and we performed gene expression analysis by microarray. Comparison of gene expression profiles (GEPs) between CLL-derived and normal monocytes was used to discover molecular abnormalit...
ORGANISM(S): Homo sapiens 
2013-01-10 | E-GEOD-35179 | biostudies-arrayexpress
GenomicsHigh density copy number analysis and whole exome sequencing of chronic lymphocytic leukemia

The pathogenesis of chronic lymphocytic leukemia (CLL), the most common leukemia in adults, is still largely unknown since the full spectrum of genetic lesions that are present in the CLL genome, and therefore the number and identity of dysregulated cellular pathways, have not been iden...

phs000364.v1.p1 | EGA
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