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TranscriptomicsRole of trisomy 21, GATAs mutation and associated mutations in the development of a DS-AMKL model from IPSC: RNAseq
Acute megakaryoblastic leukemia of Down syndrome (DS-AMKL) is a model of clonal evolution from a preleukemic transient myeloproliferative disorder requiring both a trisomy 21 (T21) and a GATA1s mutation to a leukemia driven by additional driver mutations. We modeled this leukemic evolution through s...
ORGANISM(S): Homo sapiens 
2022-09-29 | E-MTAB-11033 | biostudies-arrayexpress
TranscriptomicsHost microRNA molecular signatures associated with human H1N1 and H3N2 influenza A viruses
In this study, we performed a miRNA global profiling in human lung epithelial cells (A549) infected by two different subtypes of human influenza A viruses (H1N1 and H3N2). A549 cells were either mock-infected or infected at a multiplicity of infection (MOI) of 1 with H1N1 or H3N2 viruses, and total ...
ORGANISM(S): Homo sapiens 
2013-04-03 | E-GEOD-42003 | biostudies-arrayexpress
ProteomicsEffect of rRNA methylation defect on protein composition of human ribosomes
Ribosomal RNAs (rRNAs) are main effectors of mRNA decoding, peptide-bond formation and ribosome dynamics during translation. Ribose 2'-O-methylation is the most abundant rRNA chemical modification, and display a complex pattern in rRNA. We globally challenged rRNA 2'-O-Me by inhibiting the rRNA meth...
ORGANISM(S): Homo sapiens (Human) 
2018-04-09 | PXD007244 | Pride
Ribosomes Fibrillarin Nanolc-ms/ms 
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