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15-deoxy-delta12,14-prostaglandin J2 (15d-PGJ2) is an endogenous anti-inflammatory lipid derived from PGD2. One potential mechanism for its activity is the covalent modification of cellular proteins, via a reactive alpha,beta-unsaturated carbonyl group in its cyclopentenone ring, which in turn alter...
ORGANISM(S): Homo sapiens (Human) 
2015-04-26 | PXD000006 | Pride
Data from ProteomeXchange, PXD ID: PXD000006. Experiment: 1, file: 090712_1.8.mzml. Published as part of Proteomics. 2013 Jul;13(14):2135-9 . From the Abstract: {i}} ... In order to identify the candidate target proteins covalently modified by 15d-PGJ(2) in human aortic endothelial cell (EC), EC wa...
ORGANISM(S): Homo_sapiens_viruses, Human 
Extracellular vesicles (EV) convey biological messages through their cargoes. Herein we focus on monocyte/platelet aggregates characteristic of several cardiovascular diseases with an analysis of monocyte-derived EV (mEVs) effects on the atherosclerotic plaque. Monocyte preparations were stimulated ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD014324 | Pride
Extracellular vesicles (EV) convey biological messages through their cargoes. Herein we focus on monocyte/platelet aggregates characteristic of several cardiovascular diseases with an analysis of monocyte-derived EV (mEVs) effects on the atherosclerotic plaque. Monocyte preparations were stimulated ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD014325 | Pride
Rationale. Obesity is a risk factor for atherothrombosis and various cancers. However, the mechanisms are not completely uncovered. Objectives. We aimed to verify whether the microparticles (MPs) released from thrombin-activated platelets differed in obese and nonobese women for number, size, and p...
ORGANISM(S): Homo sapiens (Human) 
2019-02-19 | PXD011563 | Pride
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