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ProteomicsSolution study of a type I polyketide synthase from Mycobacterium tuberculosis: pks13, the condensase of mycolic acids
Background: Among the nineteen polyketide synthases encoded by the genome of Mycobacterium tuberculosis, Pks13 was identified as the condensase required for the final condensation step of two long acyl chains. This leads to mycolic acids, which are essential components of the cell envelope of Cory...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2022-05-11 | PXD029754 | Pride
Polyketide synthases Mycolic acids Bottom up Native ms Mycobacterium tuberculosis Pks13 
ProteomicsHDX-MS analysis of the full human proteasome in complex with regulators
Hydrogen-Deuterium eXchange coupled to Mass Spectrometry (HDX-MS) analysis to investigate the solvent accessibility of the full human 20S proteasome alone or in complex with PA28 regulatory particles. Our work reveals a reciprocal crosstalk between the inner and outer rings of the human 20S proteaso...
ORGANISM(S): Homo sapiens (Human) 
2020-09-11 | PXD018921 | Pride
: proteasome Hydrogen-deuterium exchange Immunoproteasome Structural biology Pa28 alpha beta Bioinformatics Pa28 gamma Structural ms 
ProteomicsProteomics analysis of Tsr1-purified yeast pre-40S particles
Proteomics analysis of pre-40S ribosomal particles.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-03-09 | PXD016577 | Pride
Tsr1 Ribosome Pre-40s particles 
ProteomicsStructural insights into the catalytic cycle of a bacterial multidrug ABC efflux pump
ABC (“ATP-Binding Cassette”) exporters of the type IV subfamily gather transporters involved in the efflux of many compounds and notably those capable to confer multidrug resistance like the mammalian P-glycoprotein or the bacterial transporter BmrA. They function according to an alternating access ...
ORGANISM(S): Bacillus subtilis 
2022-03-24 | PXD028663 | Pride
Multidrug resistance Hydrogen-deuterium exchange ms Abc transporter Bmra 
ProteomicsBidirectional signaling between nucleotide and substrate binding sites in a type IV multidrug ABC transporter
ATP-binding cassette (ABC) transporters use ATP to transport substrates across cellular membranes. In type IV ABC transporters, which includes many multidrug resistance (MDR) pumps, communication between the nucleotide-binding domains (NBDs) and transmembrane domains (TMDs) occurs via intracellular ...
ORGANISM(S): Escherichia coli 
2025-11-13 | PXD058013 | Pride
Bmra Hdx-ms Lc-msms Multidrug transporter 
ProteomicsStructural Insights into Mycobacterial Protein-Mannosyltransferase: Evidence of a WW-Domain-Like Substrate Recognition Mechanism.
We have previously demonstrated that protein-O-mannosylation (POM), a widespread post-translational glycosyl modification of proteins, is a key virulence factor of Mycobacterium tuberculosis (Mt), the world’s deadliest infectious agent. Here, we report a detailed analysis of the structure-function r...
ORGANISM(S): Escherichia coli 
2025-07-22 | PXD065654 | Pride
Glycosylation Entire protein analysis Protein-o-mannosylation Glycoprotein 
ProteomicsIsoginkgetin derivative IP2 enhances the adaptive immune response against tumor antigens
The success of cancer immunotherapy relies on the induction of an immunoprotective response targeting tumor antigens (TAs) presented on MHC-I molecules. We demonstrated that the splicing inhibitor isoginkgetin and its water-soluble and non-toxic derivative IP2 act at the production stage of the Pion...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-02 | PXD023019 | Pride
Peptidomics Lc-msms Cancer vaccine Immunopeptidomics Cancer Fibrosarcoma 
ProteomicsProteomics analysis of human pre-40S ribosomal particles
Proteomics analysis of late human pre-40S particles purified using a catalytically-inactive RIO1 as bait. Analysis of RIO1(kd)-StHA pre-40S particles composition upon RPS26 depletion with siRNA.
ORGANISM(S): Homo sapiens (Human) 
2021-05-12 | PXD019270 | Pride
Ribosomal particles 
ProteomicsMembrane-associated effluxosomes coordinate multi-metal resistance in Mycobacterium tuberculosis
Bacterial pathogens must withstand metal-induced stress during infection, yet the mechanisms by which they sense and respond to toxic metal ions remain incompletely understood. Here, we uncover a previously unrecognized mechanism in Mycobacterium tuberculosis, the causative agent of tuberculosis, wh...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2025-12-15 | PXD070650 | Pride
Metal binding Tuberculosis Native ms 
ProteomicsStructural basis of gate dynamics at the outer membrane lipopolysaccharide holo-translocon
Gram-negative bacteria resist many harmful chemicals, protected by an asymmetric outer membrane (OM) containing lipopolysaccharide (LPS) in its external leaflet. Leaflet-selective assembly of LPS is an essential, yet mechanistically elusive process. This reaction is mediated by the OM LPS core trans...
ORGANISM(S): Escherichia coli 
2025-12-01 | PXD068376 | Pride
Lps translocon Native ms Gel digestion 
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