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TranscriptomicsGene expression profiling in erythroid progenitors through ontogeny
Background: It has been reported that the phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway regulates erythropoietin (EPO)-induced survival, proliferation, and maturation of early erythroid progenitors. Erythroid cell proliferation and survival has also been related to activation of the JAK...
ORGANISM(S): Homo sapiens 
2012-05-31 | E-GEOD-37869 | biostudies-arrayexpress
TranscriptomicsNeonatal diethylstilbestrol exposure alters the metabolic profile of uterine epithelial cells.
Developmental exposure to diethylstilbestrol (DES) causes reproductive tract malformations, affects fertility and increases the risk of clear cell carcinoma of the vagina and cervix in humans. Previous studies on a well-established mouse DES model demonstrated that it recapitulates many features of ...
ORGANISM(S): Mus musculus 
2012-05-14 | E-GEOD-37969 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling by PCR array of mouse Treg cells from non-autoimmune C3H/HeOuj and lupus prone MRL/lpr strains
Comparison of Treg miRNA expression between non-autoimmune C3H/HeOuj and lupus prone MRL/lpr mice
ORGANISM(S): Mus musculus 
2011-11-30 | E-MEXP-2954 | biostudies-arrayexpress
TranscriptomicsCooperative Signaling Through the STAT3 and NF-kB Pathways in Subtypes of DLBCL
The activated B cell-like (ABC) subgroup of diffuse large B cell lymphoma (DLBCL) is characterized by constitutive activation of the NF-êB pathway. Here we show that the NF- êB pathway induces the expression of the cytokines IL-6 and IL-10 in ABC DLBCL cell lines, which also have high levels of to...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-10009 | biostudies-arrayexpress
TranscriptomicsGene expression changes in the female zebrafish (Danio rerio) brain in response to acute exposure to methylmercury
Methylmercury (MeHg) is a potent neurotoxin and endocrine disruptor that accumulates in aquatic systems. Previous studies have shown suppression of hormone levels in both male and female fish, suggesting effects on gonadotropin regulation in the brain. We investigated the gene expression profile in ...
ORGANISM(S): Danio rerio 
2010-09-30 | E-GEOD-22662 | biostudies-arrayexpress
TranscriptomicsThe scr circuit in Vibrio parahaemolyticus: output targets and transcriptional regulation by a c-di-GMP responsive protein
Vibrio parahaemolyticus scr genes modulate expression of gene sets pertinent to swarming and biofilm formation. They do so by affecting the level of the second messenger c-di-GMP. Here we explore the extent of this regulation by comparing the transcriptomes of a scrABC mutant and its wild-type paren...
ORGANISM(S): Vibrio parahaemolyticus 
2011-12-31 | E-GEOD-30508 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of nodose or dorsal root ganglion visceral sensory neurons from mice infected with N. brasiliensis and/or subjected to environmental stress to determine molecular signatures for post-infective visceral chemosensitivity associated with irritable bowel syndrome
Background & Aims: Visceral hypersensitivity, a hallmark of irritable bowel syndrome, is generally considered to be mechanosensitive in nature and mediated via spinal afferents. Both stress and inflammation are implicated in visceral hypersensitivity, but the underlying molecular mechanisms of visce...
ORGANISM(S): Mus musculus 
2008-01-31 | E-JJRD-1 | biostudies-arrayexpress
TranscriptomicsSex-related differences in gene expression following Coxiella burnetii infection: potential role of circadian rhythm
Q fever, a zoonosis due to Coxiella burnetii infection, exhibits sexual dimorphism; men are affected more frequently and severely than women for a given exposure. Here we explore whether the severity of C. burnetii infection in mice is related to differences in male and female gene expression profil...
ORGANISM(S): Mus musculus 
2010-10-02 | E-GEOD-21065 | biostudies-arrayexpress
TranscriptomicsThe TLR2 pathway is required for self-renewal of mammary cancer initiating cells
In the past few years, mammary cancer initiating cells (CICs) have been identified in mouse and human as a subpopulation of tumor cells that selectively posses tumor initiation and self-renewal capacity and the ability to give rise to bulk populations of non-tumorigenic cancer cells progeny through ...
ORGANISM(S): Mus musculus 
2013-11-30 | E-GEOD-26527 | biostudies-arrayexpress
Transcriptomicsin vitro angiogenesis miRNA Array
Angiogenesis is a complex multicellular process requiring the orchestration of many events including migration, alignment, proliferation, lumen formation, remodeling, and maturation. Such complexity indicates that not only individual genes but also entire signaling pathways will be crucial in angiog...
ORGANISM(S): Homo sapiens 
2013-09-30 | E-GEOD-50437 | biostudies-arrayexpress
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