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GenomicsMarfan syndrome rats
Marfan syndrome rat aorta
PRJEB33334 | ENA
ProteomicsBulk Mass Spectrometry in Marfan Syndrome Aortopathy
Mass spectrometry was performed using aortic tissue from patients with Marfan syndrome or healthy controls and from a mouse model of Marfan syndrome (Fbn1 C1041G/+) or wild-type controls to validate single-cell proteomics.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-09-14 | PXD079005 | Pride
Human Marfan syndrome Thoracic aorta Lc-ms/ms 
GenomicsMarfan syndrome in mice
Marfan syndrome in mice
PRJNA431794 | ENA
Proteomics17 -estradiol impedes aortic root dilation and rupture in male Marfan mice
Thoracic aortic aneurysms have a higher prevalence in male patients compared to female patients. Marfan syndrome causes a hereditary form of TAA with dilation of the aortic root. Male patients with Marfan syndrome are more likely than women to have aortic dilation and dissection and mouse models o...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-14 | PXD037853 | Pride
Marfan syndrome Estrogen Sex differences Aneurysm 
GenomicsMurine Marfan Syndrome Sildenafil Treatment
Murine Marfan Syndrome Sildenafil Treatment
PRJNA527824 | ENA
ProteomicsMarfan mouse and human aortic tissue
Thoracic aortic aneurysms and dissections (TAAD), as occur in Marfan syndrome (MFS), currently lack a cure. Our previous studies revealed that overactivation of the AKT-NO signaling pathway mediates aortic disease in MFS. However, the mechanisms upstream of AKT activation remained poorly understood....
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-06-02 | PXD077940 | Pride
Human Aortic tissue Mouse Marfan syndrome 
UnknownQuantifying the Genetic Basis of Marfan Syndrome Clinical Variability.
Not available
S-EPMC7288268 | biostudies-literature
UnknownHealth-related quality of life in children and adolescents with Marfan syndrome or related disorders: a controlled cross-sectional study.
Not available
S-EPMC11059743 | biostudies-literature
ProteomicsSingle-Cell Proteomics in Marfan Syndrome Aortopathy Uncovers Cell-Specific Proteins
To better understand mechanisms of cell organization and function in the aortas of healthy and MFS patients, we performed single cell RNA sequencing (scRNA-seq) and label-free single-cell mass spectrometry35 in aortas isolated from healthy and MFS mice and human MFS aneurysm aortic tissue. We discov...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-09-14 | PXD078860 | Pride
Marfan syndrome Aortopathy Single-cell 
GenomicsAng II type 1a receptor in Marfan syndrome
Ang II type 1a receptor in Marfan syndrome
PRJNA432050 | ENA
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