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MetabolomicsMultiple omics reveal link between the microbiota-gut-brain axis and intracranial aneurysm rupture

Intracranial aneurysms (IAs) are benign cerebrovascular maladies characterized by pathological dilatation in the walls of intracranial arteries. However, spontaneous subarachnoid hemorrhage (SAH) resulting from aneurysm rupture poses a grave threat to the patient's life. Accumulating evidence imp...

2024-12-13 | MTBLS10263 | MetaboLights
MetabolomicsFecal untargeted metabolomic profiles in aneurysmal subarachnoid hemorrhage and unruptured intracranial aneurysm
This study comprises fecal untargeted LC-MS metabolomics data from 30 participants, including 21 patients with aneurysmal subarachnoid hemorrhage and 9 patients with unruptured intracranial aneurysm. The data were generated to characterize metabolic alterations associated with disease status, inflam...
2026-07-24 | MTBLS15087 | MetaboLights
ProteomicsAortic Aneurysm iTRAQ HiRIEF proteomics
Conducted proteomics on samples from patients with aortic aneurysm and from non-dilated controls. Furthermore, we investigated both patients with bicuspid aortic valves (BAV) and also the more normal tricuspid aortic valves (TAV). The aim was to elucidate the molecular mechanisms behind the higher p...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080837 | MassIVE
ProteomicsIdentification of novel biomarkers for aortic aneurysm
To discover novel biomarkers for aortic aneurysm, serum samples of patients with thoracic aortic aneurysm were fractionated, tryptic digested, and subjected to proteome analysis.
ORGANISM(S): Homo Sapiens (human) 
2023-11-15 | PXD033774 | JPOST Repository
TranscriptomicsscRNA-seq of vertebrobasilar aneurysm in polyarteritis nodosa patient
Endovascular biopsy and fluorescence activated cell sorting was used to enrich for viable endothelial cells (ECs) from a vertebrobasilar aneurysm and the femoral artery. scRNAseq was then performed on 24 aneurysmal endothelial cells and 23 patient-matched non-aneurysmal femoral artery endothelial ce...
ORGANISM(S): Homo sapiens 
2021-07-01 | E-MTAB-10681 | biostudies-arrayexpress
TranscriptomicsMicroRNA-29 in Aortic Dilation: Implications for Aneurysm Formation
We compared the aorta of 6-weeks-old mice (young) with 18-months-old mice (old). Using the publicly available tools Sylamer and DIANA-mirExTra, we identified an enrichment for miR-29 binding sites in the 3'UTR of genes downregulated in the aged aortas. We subsequently showed that inhibition of miR-2...
ORGANISM(S): Mus musculus 
2011-10-13 | E-GEOD-32937 | biostudies-arrayexpress
TranscriptomicsTranscriptome-wide characterization of gene expression associated with unruptured intracranial aneurysms
The biological mechanisms by which cerebral aneurysms emerge, enlarge and rupture are not totally understood. In the present study, we analyzed the genome-wide gene expression profile in human intracranial aneurysms using cDNA microarrays. Intracranial arterial aneurysm samples (n = 3) and normal su...
ORGANISM(S): Homo sapiens 
2011-02-01 | E-GEOD-26969 | biostudies-arrayexpress
TranscriptomicsComparison of circular RNA microarray analysis between human unruptured and ruptured intracranial aneurysms
Arraystar Human circRNA Microarray is designed for the profiling of human circRNAs. In this study, we applied a circRNA microarray to screen the potential biomarker for intracranial aneurysm. A total of 10 samples were used to perform microarray analysis. Our study contained 2 groups, un-ruptured in...
ORGANISM(S): Homo sapiens 
2021-07-15 | E-MTAB-10683 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human patients with aortic aneurysms associated with tricuspid and bicuspid valves
Patients with bicuspid aortic valve (BAV) have increased risk of thoracic ascending aortic aneurysm (AscAA) and dissection compared to those with a normal tricuspid aortic valve (TAV). The present study was undertaken to evaluate whether differences in gene expression exist in aortas from BAV and TA...
ORGANISM(S): Homo sapiens 
2009-02-07 | E-GEOD-5180 | biostudies-arrayexpress
TranscriptomicsMicroRNA and gene expression changes in human cerebral aneurysms [RNA-seq]
Cerebral Aneurysm tissues and superficial temporal arteries were compared through RNA-Seq to identify differentially expressed genes, and through microRNA microarray to identify differentially expressed microRNAs. Significant miR:gene pairs were identified for potential microRNA silencing regualtory...
ORGANISM(S): Homo sapiens 
2016-02-24 | E-GEOD-66238 | biostudies-arrayexpress
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