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TranscriptomicsSRT1720 extends healthspan and lifespan in diet-induced obese mice
Activation of Sirt1, the mammalian homolog of an NAD+-dependent deacetylase known to modulate lifespan in lower organisms, is thought to hold promise as a strategy for delaying aging in mammals. SRT1720, a novel compound developed as a specific and potent activator of Sirt1, has shown promising effe...
ORGANISM(S): Mus musculus 
2011-08-17 | E-GEOD-19102 | biostudies-arrayexpress
GenomicsNHLBI GO-ESP: Family Studies (Familial Interstitial Pneumonia)

The NHLBI "Grand Opportunity" Exome Sequencing Project (GO-ESP), a signature project of the NHLBI Recovery Act investment, was designed to identify genetic variants in coding regions (exons) of the human genome (the "exome") that are associated with heart, lung and blood diseases. These and relat...

phs000582.v1.p1 | EGA
GenomicsNational Cancer Institute Genome-Wide Association Study of Renal Cell Carcinoma

The National Cancer Institute (NCI) genome-wide association study (GWAS) of renal cell carcinoma (RCC) was conducted to investigate common genetic variants associated with RCC risk. The GWAS includes 1,453 RCC cases and 3,531 controls of European background from 4 studies (3 cohort, 1 case-con...

phs000351.v1.p1 | EGA
TranscriptomicsAge Map, Cerebellum (A)
To assess the transcriptional changes in different brain regions and spinal cord associated with aging and either a caloric restricted (CR) or ad libitum (AL) diet. cDNA microarray and quantitative PCR analyses were used to examine the transcriptomes of various neuronal tissues in young, middle aged...
ORGANISM(S): Mus musculus 
2009-06-21 | E-GEOD-8409 | biostudies-arrayexpress
TranscriptomicspCREB-dependent transcriptional activation is a mediator of molecular neuroadaptations induced by methamphetamine self-administration in the rat dorsal striatum
Neuroplastic changes in the dorsal striatum participate in the transition from casual drug use to habitual and compulsive drug taking. These alterations might also play a critical role in the development of methamphetamine (METH) addiction. Nevertheless, the molecular substrates that underlie habitu...
ORGANISM(S): Rattus norvegicus 
2012-05-31 | E-GEOD-38223 | biostudies-arrayexpress
TranscriptomicsMalaria Host Pathogen Interaction Center: Gene and exon transcript abundances of uninfected Macaca mulatta treated with pyrimethamine over 7 time points in a 100 day study
The Malaria Host-Pathogen Interaction Center (MaHPIC) is an inter-disciplinary NIH systems biology contract that utilizes multiple omics types (omics, clinical, and mathematical models), to iteratively test and develop hypotheses related to the complex host-parasite dynamics in the course of malari...
ORGANISM(S): Macaca mulatta 
2014-10-10 | E-GEOD-58340 | biostudies-arrayexpress
ProteomicsPrimary human airway epithelial cells metabolome response to an icMERS coronavirus
Metabolomics data from cell culture; time points 0, 12, 24, 36 & 48 h
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Middle East Respiratory Syndrome-related Coronavirus (ncbitaxon:1335626) 
2018-01-05 | MSV000081891 | MassIVE
ProteomicsCalu-3 cell lipidome response to a wild type H5N1 and mutants Influenza viruses
Lipidomics data from Calu-3 cell culture; Treated with wild-type and mutant H5N1 and mockulum; Time points 0, 3, 7, 12, 18 & 24 h; 5 biological replicates
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-08-04 | MSV000080023 | MassIVE
ProteomicsHuman Calu-3 cell proteome response to a wild type infectious clone of H5N1 and mutant H5N1 viruses
Lipidomics data from Calu-3 cell culture; Treated with wild-type and mutant H5N1 and mockulum; Time points 0, 3, 7, 12, 18 & 24 h; 5 biological replicates
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2016-01-18 | MSV000079459 | MassIVE
ProteomicsCalu-3 metabolome response to an infectious clone of H7N9 Influenza virus and mutant H7N9 viruses
Metabolomics data from Calu-3 cell culture; Treated with wild-type and mutant H7N9 and mockulum; Time points 0, 3, 7, 12, 18 & 24 h; 5 biological replicates
ORGANISM(S): Human Calu-3 Cell Homo Sapiens (ncbitaxon:9606) 
2015-06-11 | MSV000079156 | MassIVE
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