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ProteomicsFast light changes promote distinct responses of plastid protein acetylation marks
Protein acetylation is a key recurring co- and posttranslational modification. How different types of acetylation respond to the same environmental stress is unknown. A member of the newly discovered family of plastid acetyltransferases (GNAT2), which is featuring both lysine- and N-terminal acetyl...
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress) 
2024-08-19 | PXD040517 | JPOST Repository
ProteomicsEarly NK-cell and T-cell dysfunction marks progression to severe dengue in patients with obesity and healthy weight
Dengue is a mosquito-borne virus infection affecting half of the world’s population for which therapies are lacking. The role of T and NK-cells in protection/immunopathogenesis remains unclear for dengue for dengue. We performed a longitudinal phenotypic, functional and transcriptional analyses of T...
ORGANISM(S): Homo sapiens (Human) 
2025-05-21 | PXD061694 | Pride
Dengue Cd4+ t-cells Cd8+ t-cells Co-inhibitory receptors Cytotoxic cells Severe dengue biomarkers Nk-cells Type-i ifn 
GenomicsChIP-seq of CSF-1R, H3K4me1, H3K4me3 in human primary unstimulated monocytes and monocytes differentiated 72h with CSF-1 (3 healthy donors buffy coat) and in monocytes from two CMML patients and one healthy donor, EGR1 ChIP-seq in unstimulated monocytes (3 healthy donors buffy coat)
Identification of nuclear CSF-1R, H3K4me1 and H3K4me3 localization on chromatin in human primary monocytes and modification of this localization during monocyte differentiation into macrophage induced by 100ng/mL CSF-1 during 6 hours (1 donor) or 72h (3 donors). Identification of EGR1 chromatin loc...
ORGANISM(S): Homo sapiens 
2019-03-04 | E-MTAB-6305 | biostudies-arrayexpress
GenomicsGlobal epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci
Identifying cis-regulatory elements is important to understand how human pancreatic islets modulate gene expression in physiologic or pathophysiologic (e.g., diabetic) conditions. We conducted genome-wide analysis of DNase I hypersensitive sites, histone H3 lysine methylation marks (K4me1, K4me3, K7...
ORGANISM(S): Homo sapiens 
2010-11-02 | E-GEOD-23784 | biostudies-arrayexpress
TranscriptomicsArabidopsis AGO5 contributes to a POL II-based RNA silencing pathway directing epigenetic marks
To characterise the Arabidopsis AGO5 protein, we report the AGO5 associated sRNAs, ago5 mutant total sRNAs and digital gene indexing tags with altered abundance in the ago5 mutant. Examination of AGO5 associated sRNAs, population of total sRNAs in the ago5 mutant and characterisation of RNA transcri...
ORGANISM(S): Arabidopsis thaliana 
2014-07-27 | E-GEOD-30970 | biostudies-arrayexpress
ProteomicsData for: A practical guide for analysis of histone post-translational modifications by mass spectrometry: best practices and pitfalls
Histone proteomics from 5 human cell lines, discussed in publication: "A practical guide for analysis of histone post-translational modifications by mass spectrometry: best practices and pitfalls". Further explanation of data types, methods, and analysis are available in Data Explanation document in...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084298 | MassIVE
TranscriptomicsHistone H3.3 is required for endogenous retroviral element silencing and genome stability [RNA-Seq]
Endogenous retroviruses (ERVs) have provided an evolutionary advantage in the diversification of transcript regulation and are thought to be involved in the establishment of extraembryonic tissues during development. However, silencing of these elements remains critical for the maintenance of genome...
ORGANISM(S): Mus musculus 
2015-05-05 | E-GEOD-59104 | biostudies-arrayexpress
Genomicsena-DATASET-BLUEPRINT-16-03-2018-14:03:53:512-282 - samples
Analysis of the reference epigenomes and regulatory landscape of CLL as a whole and its major clinico-biological subtypes (with mutated and unmutated IGHV) in the light of the normal B-cell differentiation. We have extensively characterized the reference epigenomes of seven primary chronic lymphocy...
EGAD00001004046 | EGA
UnknownProstate Health Index improves multivariable risk prediction of aggressive prostate cancer.
Not available
S-EPMC5392379 | biostudies-literature
TranscriptomicsMeis1 coordinates a network of genes implicated in eye development and microphthalmia
Microphthalmos is a rare congenital anomaly characterized by reduced eye size and visual deficits of variable degrees. Sporadic and hereditary microphthalmos has been associated to heterozygous mutations in genes fundamental for eye development. Yet, many cases are idiopathic or await the identifica...
ORGANISM(S): Mus musculus 
2015-08-27 | E-GEOD-62786 | biostudies-arrayexpress
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