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ProteomicsFUCCI Based Study of Toxoplasma Endodyogeny
In this study, we report the first application of the Fluorescent Ubiquitination-based Cell Cycle Indicator (FUCCI) in a unicellular eukaryote model. We created the ToxoFUCCIS and Toxo FUCCISC probes. Our analysis of ToxoFUCCIS and its derivatives co-expressing epitope- tagged cell cycle markers hav...
ORGANISM(S): Toxoplasma gondii ME49 
2025-06-30 | PXD054719 | Pride
Endodyogeny Cell cycle Toxoplasma. fucci Lc-ms/ms 
ProteomicsG2 Phase Controls Binary Division of Toxoplasma gondii
The current study investigates the roles of a novel essential cell cycle kinase TgCrk4. We identified this kinase aalong with its cyclin partner and demonstrated that TgCrk4 regulates processes carried out during conventional G2 phase, such as repression of chromosome re-replication and centrosome r...
ORGANISM(S): Toxoplasma gondii ME49 
2024-06-23 | PXD050478 | Pride
Toxoplasma Tgcyc4 Tgcrk4 G2 
ProteomicsToxoplasma gondii Cyclin-4 Interactome
Toxoplasma endodyogeny is governed by a set of Cdk-related kinases (Crk). In this study we investigated TgCrk4 and its cyclin partner TgCyc4. This complex regulates many cell cycle related processes at the G2 phase. To beter undestand the funtion of the TgCrk4/TgCyc4 complex we analyzed the interact...
ORGANISM(S): Toxoplasma gondii ME49 
2024-06-16 | PXD043994 | Pride
Toxoplasma gondi Cyclin-4 Lc-ms/ms 
ProteomicsToxoplsama gondii Cdt1 homolg interactome
Toxoplasma endodyogeny is governed by a set of Cdk-related kinases (Crk). In this study we investigated TgCrk4 and its cyclin partner TgCyc4. This complex regulates many cell cycle related processes at the G2 phase. We identified an interactor of this complex TgCdt1 and analyzed its interactome usin...
ORGANISM(S): Toxoplasma gondii ME49 
2024-06-16 | PXD043924 | Pride
Toxoplasma gondii Interactome Cdt1 Lc-ms/ms 
ProteomicsToxoplasma gondii Crk4 interactome
Toxoplasma endodyogeny is governed by a set of Cdk-related kinases (Crk). In this study we investigated TgCrk4 and its cyclin partner TgCyc4. This complex regulates many cell cycle related processes at the G2 phase. To beter undestand the funtion of the TgCrk4/TgCyc4 complex we analyzed the interact...
ORGANISM(S): Toxoplasma gondii ME49 
2024-06-16 | PXD044592 | Pride
Toxolasma gondii Crk4 Cyclin-4 Lc-ms/ms 
ProteomicsT. gondi COG complex interactors LC-MS/MS
COG complexes are important proteins involved in the tethering and fusion of recycling vesicles in golgi cisternae. We investigated COG complexes in T. gondii and identified all 8 subunits to be present. We also looked into different interactors of COG and identified two novel proteins of interest. ...
ORGANISM(S): Toxoplasma gondii ME49 
2025-06-30 | PXD041887 | Pride
Cog complex Toxoplama 
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