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ProteomicsA functional genomics screen identifies genes required for Schizosaccharomyces pombe meiosis
Meiosis is a specialized cell division that generates gametes, such as eggs and sperm. Errors in meiosis result in miscarriages and are the leading cause of birth defects, however the molecular origins of these defects remain unknown. Studies in model organisms are beginning to identify the genes an...
ORGANISM(S): Schizosaccharomyces pombe 
2018-01-04 | PXD008245 | Pride
Schizosaccharomyces pombe Chromosome segregation Sporulation Meiosis 
ProteomicsRewiring of the phosphoproteome executes two meiotic divisions
The cell cycle is ordered by a controlled network of kinases and phosphatases. To generate gametes via meiosis, two distinct and sequential chromosome segregation events occur without an intervening S phase. How canonical cell cycle controls are modified for meiosis is not well understood. Here, usi...
ORGANISM(S): Saccharomyces cerevisiae Saccharomyces cerevisiae (Baker's yeast) 
2026-09-12 | PXD045368 | Pride
Spo13 Saccharomyces cerevisiae Kinases Phosphorylation Meiosis Cell cycle 
ProteomicsThe proteomic landscape of centromeric chromatin reveals an essential role for the Ctf19 complex in meiotic kinetochore assembly.
Faithful gamete formation during meiosis requires that kinetochores take on new functions that impact homolog pairing/recombination and their attachments to microtubules. We used a proteomics pipeline to determine the global composition of centromeric chromatin and kinetochores at distinct meiotic s...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-02-23 | PXD019754 | Pride
Kinetochores Saccharomyces cerevisiae Meiosis Chromatin Label-free quantitation. 
ProteomicsMudPIT analyses of the protein succination after fumarate treatment of whole cell extracts from Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) fumarate hydratase-deficient (FH-/-) cells
In brief, TCA-precipitated proteins from whole cell extracts treated with fumarate were urea-denatured, reduced, alkylated, and digested with endoproteinase LysC followed by trypsin. The peptide mixtures were loaded onto microcapillary fused silica columns (100um i.d.), packed with C18 reverse phase...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-03-13 | MSV000082160 | MassIVE
ProteomicsRewiring of the phosphoproteome executes two meiotic divisions
The cell cycle is ordered by a controlled network of kinases and phosphatases. To generate gametes via meiosis, two distinct and sequential chromosome segregation events occur without an intervening S phase. How canonical cell cycle controls are modified for meiosis is not well understood. Here, usi...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-03-21 | PXD048618 | Pride
Spo13 Saccharomyces cerevisiae Kinases Phosphorylation Meiosis 
UnknownMutations in repeating structural motifs of tropomyosin cause gain of function in skeletal muscle myopathy patients.
Not available
S-EPMC3836477 | biostudies-literature
UnknownSetting the research agenda for living with and beyond cancer with comorbid illness: reflections on a research prioritisation exercise.
Not available
S-EPMC7191759 | biostudies-literature
GenomicsShugoshin biases chromosomes for biorientation through condensin recruitment to the pericentromere
To protect against aneuploidy, chromosomes must attach to microtubules from opposite poles (“biorientation”) prior to their segregation during mitosis. Biorientation relies on the correction of erroneous attachments by the aurora B kinase, which destabilizes kinetochore-microtubule attachments that ...
ORGANISM(S): Saccharomyces cerevisiae W303 
2014-01-08 | E-GEOD-53856 | biostudies-arrayexpress
UnknownFamily-based prevention programmes for alcohol use in young people.
Not available
S-EPMC6423557 | biostudies-literature
UnknownMapping small mammal optimal habitats using satellite-derived proxy variables and species distribution models.
Not available
S-EPMC10434852 | biostudies-literature
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