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ProteomicsA CSB-PAF1 axis activates RNA polymerase II from promoter-proximal sites and restores efficient transcription elongation after DNA damage repair
The coordinated transcription of genes involves RNA polymerase II enzymes (RNAPII), which pull DNA through their active sites. DNA lesions in transcribed strands block RNAPII elongation and induce a strong transcriptional arrest. The transcription-coupled repair (TCR) pathway ensures the efficient r...
ORGANISM(S): Homo sapiens (Human) 
2021-02-28 | PXD016198 | Pride
Csb Tc-ner Transcription recovery 
UnknownNucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response.
Not available
S-EPMC2753161 | biostudies-literature
UnknownDual Modes of Gene Regulation by CDK12.
Not available
S-EPMC12485715 | biostudies-literature
UnknownDNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1.
Not available
S-EPMC6172278 | biostudies-literature
UnknownAPEX1 Nuclease and Redox Functions are Both Essential for Adult Mouse Hematopoietic Stem and Progenitor Cells.
Not available
S-EPMC10390635 | biostudies-literature
UnknownUltra-soft X-ray system for imaging the early cellular responses to X-ray induced DNA damage.
Not available
S-EPMC6753493 | biostudies-literature
ProteomicsTranscription-coupled DNA-Protein Crosslink repair by CSB and CRL4(CSA)-mediated degradation
DNA-protein crosslinks (DPCs), arise from enzymatic intermediates, endogenous metabolism or exogenous chemicals like chemotherapeutics. DPCs are highly cytotoxic as they will impede DNA transacting processes such as replication, which is counteracted by proteolysis-mediated DPC removal by the protea...
ORGANISM(S): Homo sapiens (Human) Caenorhabditis elegans 
2024-02-09 | PXD041679 | Pride
Tc-ner Silac Csb Csa 
UnknownTranscription-coupled DNA-protein crosslink repair by CSB and CRL4<sup>CSA</sup>-mediated degradation.
Not available
S-EPMC11098752 | biostudies-literature
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