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ProteomicsNanobody-mediated modulation of long RSH enzymes Rel and RelA catalysis by restriction of their conformational landscape
Long RSH enzymes, Rel and RelA, are the master regulators of (p)ppGpp alarmone levels in bacteria. Their catalytic activity is governed by transitions between a compact, hydrolysis-competent (HDON) state and an elongated, synthesis-competent (SYNTHON) state. The equilibrium between these states is m...
ORGANISM(S): Escherichia coli 
2026-04-28 | PXD067451 | Pride
Structural biology Rsh enzymes Nanobodies 
ProteomicsHDX-MS on secondary transporters
Secondary transporters undergo structural rearrangements to catalyze substrate translocation across the cell membrane – yet how such conformational changes happen within a lipid environment remains poorly understood. Here, we combine hydrogen-deuterium exchange mass spectrometry (HDX-MS) with molecu...
ORGANISM(S): Escherichia coli 
2018-10-16 | PXD011060 | Pride
Conformational dynamics Structural biology Membrane proteins Lipid-protein interactions 
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