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TranscriptomicsIN VITRO SYSTEMS TOXICOLOGY ASSESSMENT OF A PROTOTYPIC MODIFIED RISK TOBACCO PRODUCT SHOWS REDUCED TOXICITY COMPARED TO A CONVENTIONAL CIGARETTE
The toxicity and potential associated molecular mechanism of a reference cigarette, 3R4F and THS2.2 a candidate modified risk tobacco products ((p)MRTP) were investigated with human bronchial epithelial cells using high-throughput screening and whole transcriptomics analysis.
ORGANISM(S): Homo sapiens 
2016-01-05 | E-MTAB-3738 | biostudies-arrayexpress
ProteomicsSplenectomy of patients with hereditary spherocytosis improves erythrocyte functionality in a septin-dependent manner
Splenectomy improves clinical parameters of patients with hereditary spherocytosis but its potential benefit to red blood cell (RBC) morphology and deformability and the mechanism behind remain unknown. We here compared 7 non-splenectomized and 12 splenectomized patients with mutations in the β-spec...
ORGANISM(S): Homo sapiens (Human) 
2023-02-13 | PXD034588 | Pride
Calcium Red blood cell fragility Oxidative stress Extracellular vesicle release Rbc maturation Spectrin network Ankyrin 
TranscriptomicsTranscription profiling of human gliomas reveals wavelet modelling of microarray data provides chromosomal pattern of expression which predicts survival
Genetic and epigenetic processes result in gene expression changes through alteration of the chromatin structure. The relative position of genes on chromosomes has therefore important functional implications and can be exploited to model microarray datasets. Gliomas are the most frequent primary b...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2817 | biostudies-arrayexpress
TranscriptomicsIdentification of genes involved in the establishment of plant-microorganism interactions
affy_pathogen_medicago - In compatible interaction between plants and biotrophic microorganisms, neoformation of organs occurs to ensure an efficient relationship between both partners. During the interaction between Medicago truncatula and Sinorhizobium meliloti, bacteria induce the development of ...
ORGANISM(S): Medicago truncatula 
2012-03-01 | E-GEOD-19872 | biostudies-arrayexpress
UnknownImpact of autoantibody status on stratifying the risk of organ involvement and mortality in SSc: experience from a multicentre French cohort of 1605 patients.
Not available
S-EPMC11580297 | biostudies-literature
TranscriptomicsCharacterization of PlcRa, a new PlcR-like regulator involved in oxidative stress response and cysteine metabolism during early stationary phase in Bacillus cereus
PlcR, the major virulence transcriptional regulator in the Bacillus cereus group belongs to the RNPP quorum sensor family and is activated through interaction with the secreted heptapeptide PapR7 used as a signalling molecule. We identified using modeling analysis a structural homologue of PlcR, Plc...
ORGANISM(S): Bacillus cereus ATCC 14579 
2012-12-14 | E-GEOD-30514 | biostudies-arrayexpress
UnknownAirway microbiota signals anabolic and catabolic remodeling in the transplanted lung.
Not available
S-EPMC5792246 | biostudies-literature
TranscriptomicsA novel class of alternative 3M-bM-^@M-^Y-terminal exons is involved in cell-cycle regulation by topoisomerase inhibitors
Alternative 3M-bM-^@M-^Y-terminal exons, which use intronic polyadenylation sites, are generally unconserved and lowly expressed, while the main gene products end in the last exon of genes. In this study, we discover a class of human genes, where the last exon appeared recently during evolution, and...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-53474 | biostudies-arrayexpress
TranscriptomicsCotranscriptional exon skipping in the genotoxic stress response
Pre-mRNA splicing is functionally coupled to transcription, and genotoxic stresses can enhance alternative exon inclusion by affecting elongating RNA polymerase II. We report here that various genotoxic stress inducers, including camptothecin, inhibit the interaction between EWS, an RNA polymerase I...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-21840 | biostudies-arrayexpress
UnknownRelationship between regulatory T cells and immune activation in human immunodeficiency virus-infected patients interrupting antiretroviral therapy.
Not available
S-EPMC2908121 | biostudies-literature
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