Martin Evelyn E

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Cerebrospinal fluid markers to distinguish bacterial meningitis from cerebral malaria in children

Clinically distinguishing acute bacterial meningitis from cerebral malaria, both of which are important causes of acute non-traumatic coma associated with morbidity and mortality among paediatric hospital admissions in malaria endemic areas of Africa, is challenging. Few hospitals have diagnostic ca...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2017-04-24 | MSV000080979 | MassIVE

Genome-wide association studies of TDP-43 proteinopathy and hippocampal sclerosis reveal shared genetic associations with APOE and TMEM106B.

Not available

S-EPMC12598407 | biostudies-literature

Treatment resistance to platinum-based chemotherapy in lung and ovarian cancer is driven by a targetable TGFβ senescent secretome.

Not available

S-EPMC12920146 | biostudies-literature

Resveratrol Diet Aging (Heart, Liver, Muscle and Fat Tissue)

Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending lifespan A small molecule that safely mimics the ability of dietary restriction (DR) to delay age-related diseases in laboratory animals is greatly sought after. We and others ha...

ORGANISM(S): Mus musculus

2008-08-04 | E-GEOD-11845 | biostudies-arrayexpress

Genome-wide profiling of p63 binding sites identifies genes and regulatory elements for p63-related disorders

We identified p63 target genes and binding sites responsible for ectodermal defects by genome-wide profiling of p63 binding using ChIP-seq and expression analysis in human primary keratinocytes from patients with p63 mutations. As proof of principle, we identified a novel de novo microdeletion causi...

ORGANISM(S): Homo sapiens

2010-08-15 | E-GEOD-17611 | biostudies-arrayexpress

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.

Not available

S-EPMC4314944 | biostudies-literature

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.

Not available

S-EPMC5669039 | biostudies-literature

Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease.

Not available

S-EPMC12273372 | biostudies-literature

Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.