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TranscriptomicsMC EMiNEM Maps the Interaction Landscape of the Mediator
By applying MC EMiNEM (a novel method based on the concept of Nested Effects Models (NEMs) for the retrieval of functional dependencies between proteins that have pleiotropic effects on mRNA transcription) to the expression data from four gene perturbation studies (three of them unpublished) in Sacc...
ORGANISM(S): Saccharomyces cerevisiae 
2012-06-01 | E-MTAB-1037 | biostudies-arrayexpress
UnknownStabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition.
Not available
S-EPMC11145177 | biostudies-literature
MetabolomicsHost-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles
Recent development of benzoxaborole-based chemistry gave rise to a collection of compounds with great potential in targeting diverse infectious diseases, including human African Trypanosomiasis (HAT), a devastating neglected tropical disease. However, further medicinal development is largely restric...
2018-02-12 | MTBLS452 | MetaboLights
UnknownPathologic and molecular features correlate with long-term outcome after adjuvant therapy of resected primary GI stromal tumor: the ACOSOG Z9001 trial.
Not available
S-EPMC4026579 | biostudies-literature
MetabolomicsLeptin increases hepatic triglyceride export via a vagal mechanism in humans
Recombinant human leptin (metreleptin) reduces hepatic lipid content in patients with lipodystrophy and overweight patients with non-alcoholic fatty liver disease and relative hypoleptinemia independent of its anorexic action. In rodents, leptin signaling in the brain increases very-low-density lipo...
2023-06-07 | MTBLS4231 | MetaboLights
UnknownUsing high-resolution residential greenspace measures in an urban environment to assess risks of allergy outcomes in children.
Not available
S-EPMC6563346 | biostudies-literature
MetabolomicsComprehensive systems biology analysis of a seven-month cigarette smoke inhalation study in C57BL/6 mice
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of smoke derived from a prototype modified risk tobacco product (pMRTP) as compare...
2015-11-19 | MTBLS143 | MetaboLights
ProteomicsIdentification of KRas interactors in pancreatic cancer cell lines growing on matrix of different rigidities
KRas is one of the most prevalent mutations in pancreatic cancer and derives diverse signalling cascades to support tumour initiation and progression. Pancreatic ductal adenocarcinoma (PDAC) is the most diagnosed type of pancreatic cancer and is characterized to have a very dense stromal rigidity. T...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD069885 | Pride
Lc-ms-ms Integrins Pancreatic cancer. pdac Mass spectrometry Kras 
UnknownCabozantinib in progressive medullary thyroid cancer.
Not available
S-EPMC4164813 | biostudies-literature
UnknownMutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy.
Not available
S-EPMC8748873 | biostudies-literature
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