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TranscriptomicsSepsis induces long-lasting impairments in T helper cell responses despite rapid numerical recovery of T-lymphocyte populations
Our experiments examined T-lymphocyte numbers and effector-functions in peritoneal contamination and infection (PCI) a mouse model of sepsis. One of our main questions was how T-lymphocytes reconstitute after sepsis-induced lymphopenia. We investigated the quantitative and qualitative recovery of T ...
ORGANISM(S): Mus musculus 
2019-10-02 | E-MTAB-7483 | biostudies-arrayexpress
TranscriptomicsExpression Data from Memory P14 Tg CD8 T cells after either saline mock-infection, Pichinde Virus Infection (bystander infection) or Pichinde Virus infection with daily treatment with anti-CD122 (clone TM-b1)
Exposure to inflammatory cytokines driven by bystander cytokines can have profound effects on the function of memory CD8 T cells. Here we transferred a 1-5X10^4 of P14 TCR-tg T cells (specific for gp33-41 of LCMV) on day -1 followed by infection with 2X10^5 PFU of LCMV Armstrong ip to generate memor...
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-69791 | biostudies-arrayexpress
TranscriptomicsCentral Role of Th2 and Tc2 Lymphocytes in Multiple Sclerosis Pattern II Demyelinating Lesions
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system with marked heterogeneity in several aspects including pathological processes. Four histopathological patterns of MS have been described. Pattern II is characterized by antibody and complement depos...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-60914 | biostudies-arrayexpress
UnknownUromodulin rs4293393 T>C variation is associated with kidney disease in patients with type 2 diabetes.
Not available
S-EPMC5890591 | biostudies-literature
TranscriptomicsGene expression profiling of in vitro derived induced and natural FOXP3+ regulatory T cells and ex-iTreg cells in the mouse
Induced Treg (iTreg) cells are essential for tolerance and can be used therapeutically, yet their stability in vivo and mechanisms of suppression are unresolved. Here, we used a treatment model of colitis to examine the role of autologous IL-10 in iTreg cell function. Mice treated with IL-10+/+ iTr...
ORGANISM(S): Mus musculus 
2012-12-06 | E-GEOD-35543 | biostudies-arrayexpress
UnknownGranzyme B-induced and caspase 3-dependent cleavage of gelsolin by mouse cytotoxic T cells modifies cytoskeleton dynamics.
Not available
S-EPMC2881814 | biostudies-literature
UnknownFibroblast activation protein (FAP)-mediated promotion of metastasis via the FN1-TGFβ axis and immune suppression in aggressive thyroid cancer.
Not available
S-EPMC12616960 | biostudies-literature
UnknownSexual and Emotional Health after Allogeneic Hematopoietic Cell Transplantation: A Comprehensive Review and Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC).
Not available
S-EPMC8911485 | biostudies-literature
TranscriptomicsTranscription profiling of mouse spleen after immunized using LPS vs MPL as adjuvant.
An unresolved issue in immunology is the extent to which inflammatory effects are needed for robust T cell responses. In this study, mice were immunized by iv injection using either high toxicity lipopolysaccharide (LPS) or low toxicity monophosphoryl lipid A (MPL) as adjuvant. Six hours after iv ...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7768 | biostudies-arrayexpress
TranscriptomicsCharacterization of a P-REX1 gene signature in breast cancer cells
The Rac nucleotide Exchange Factor (Rac-GEF) P-Rex1 is highly expressed in breast cancer, specifically in the luminal subtype, and is an essential mediator of actin cytoskeleton reorganization and cell migratory responses induced by ErbB and other tyrosine-kinase receptors. Heregulin, a growth facto...
ORGANISM(S): Homo sapiens 
2016-09-07 | E-GEOD-77974 | biostudies-arrayexpress
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