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TranscriptomicsDynamics of Virus-specific CD8+ T cells in the Human Nasal Cavity
The goal of this experiment is to compare the transcriptomic profile of CD8+ T cells isolated from the nasal cavity and whole blood at two different state, baseline and CD3/28 activated. This will allow us to characterise the unique features of CD8+ T cells in the nasal cavity. We isolated CD8+CD4...
ORGANISM(S): Homo sapiens 
2025-08-23 | E-MTAB-15436 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD4+/CD8+ T cells obtained from HIV patients at various stages of disease vs. uninfected individuals reveals HIV infection induces a persistent T cell transcriptional profile
We examined the gene expression profiles in ex vivo human CD4+ and CD8+ T cells from untreated HIV-infected individuals at different clinical stages and rates of disease progression. Profiles of pure CD4+ and CD8+ T cells subsets from HIV-infected nonprogressors who controlled viremia were indisting...
ORGANISM(S): Homo sapiens 
2007-11-11 | E-GEOD-6740 | biostudies-arrayexpress
TranscriptomicsCXCL12/CXCR4 signaling mediates niche occupancy and tumor maintenance in T-cell leukemia
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy characterized by infiltration of the bone marrow and other sites with transformed T cell progenitors. The role of tissue microenvironments in the pathogenesis of T-ALL or any other type of acute leukemia is little ...
ORGANISM(S): Mus musculus 
2015-08-12 | E-GEOD-60367 | biostudies-arrayexpress
TranscriptomicsSingle-cell multiome analysis of human in vitro activated CD4 T cells
This study looks at the ATAC+RNA profiles of human CD4 T cells under bioreactor-like conditions as ACT. Cells were stimulated toward Th1,Th2,Treg and Th17 under anti-CD3/28 activation, and profiled on day 5.
ORGANISM(S): Homo sapiens 
2024-01-31 | E-MTAB-13711 | biostudies-arrayexpress
TranscriptomicsFriends not foes: CTLA-4 blockade and mTOR inhibition cooperate during CD8+ T cell priming
T cells receive numerous positive and negative signals during primary antigen encounter that control their proliferation and function, but how these signals are integrated to modulate T cell memory has not been fully characterized. In these studies, we demonstrate that combining seemingly opposite ...
ORGANISM(S): Mus musculus 
2015-01-31 | E-GEOD-63022 | biostudies-arrayexpress
TranscriptomicsMemory-like CD8 T-cells sustain the immune response to chronic viral infections.
We have discovered a small subpopulation of virus-specific CD8 T-cells that sustains the T-cell response in chronic infections. These cells are defined by - and depend on - the expression of the transcription factor Tcf1 (T cell factor 1) and show key characteristics of central memory cells while ...
ORGANISM(S): Mus musculus 
2016-08-22 | E-GEOD-83978 | biostudies-arrayexpress
ProteomicsProteomics from centrosome-enriched fractions from resting and activated T lymphoblasts
Human resting and activated T lymphoblast (LT CTRL and LT ACT) centrosome-enriched subcellular fractions from LT CTRL and LT ACT were prepared as analysed by multiplexed quantitative proteomics and LC-MS/MS. Samples from different donors were pooled after first lysis. For further details, refer to r...
ORGANISM(S): Homo sapiens (Human) 
2025-12-18 | PXD063195 | Pride
T lymphoblasts Post-translational modifications Human Itraq Lc-ms/ms 
TranscriptomicsExpression data from stimulated or unstimulated human CD4+ T cells incubated with edelfosine
The cytotoxic drug edelfosine is a synthetic analog of 2-lysophosphatidylcholine. Edelfosine is incorporated by highly proliferating cells, e.g. activated immune cells. It is unknown if the described mechanisms for edelfosine action attained by in vitro approaches exclusively contribute to the obser...
ORGANISM(S): Homo sapiens 
2014-05-06 | E-GEOD-44392 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of WT and NFAT2 KO follicular helper CD4 T cells and non follicular helper CD4 T cell populations
Comparatative gene expression analysis for wild type and NFAT2-/- CD4 T cell subsets including follicular helper CD4+ T (TFH) cells, activated CD4+ T cells, and naive CD4+ T cells isolated from the spleen.
ORGANISM(S): Mus musculus 
2014-02-21 | E-MEXP-3820 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human prolymphocytic leukemina T-cells and normal T-cells
T-cell prolymphocytic leukemina (T-PLL) is an agressive lymphoma derived from mature T-cells, which is in most cases characterized by the presence of an inv(14)(q11q32) and a characteristic pattern of secondary chromosomal abberations. We used microarrays to compare the transcriptomes of eight immun...
ORGANISM(S): Homo sapiens 
2008-12-10 | E-GEOD-5788 | biostudies-arrayexpress
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