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ProteomicsDifferential patterns of protein expression in monolayer or spheroid melanoma cell models of acquired resistance to BRAF and MEK1/2 inhibitors
Mitogen activated protein kinase (MAPK) inhibitors are important therapies for treating many cancers. However, the development of acquired resistance to most protein kinase inhibitors limit their ability to provide durable responses. Approximately 50% of malignant melanomas contain activating mutati...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026952 | Pride
Monolayer Braf Drug resistance Protein kinases Kinase targeted therapy Selumetinib Spheroids Melanoma Vemurafenib Extracellular-signal regulated kinases 
ProteomicsPlastic associated endocrine disruptors reduce Nicastrin protein and potentiate inflammation in Hidradenitis Suppurativa skin disease
Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition often characterized by nodules, cysts, and tunneling sinus tracts. Incidence of HS varies by study, anywhere from 0.1% to 2% of the general population, and is increasing over time. Despite its common occurrence, the only FDA appr...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD068006 | Pride
Nicastrin Skin Hidradenitis suppurativa Imaging 
UnknownDexamethasone in Hospitalized Patients with Covid-19.
Not available
S-EPMC7383595 | biostudies-literature
UnknownEffect of Hydroxychloroquine in Hospitalized Patients with Covid-19.
Not available
S-EPMC7556338 | biostudies-literature
UnknownAzithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC7884931 | biostudies-literature
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