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ProteomicsQuantitative Proteomics Reveals that the OGT Interactome is Remodeled in Response to Oxidative Stress
The dynamic modification of specific serine and threonine residues of intracellular proteins by O-linked N-acetyl-β-D-glucosamine (O-GlcNAc) mitigates injury and promotes cytoprotection in a variety of stress models. The O-GlcNAc transferase (OGT) and the O-GlcNAcase (OGA) are the sole enzymes that ...
ORGANISM(S): Mus Musculus 
PXD021091 | panorama
ProteomicsO-GlcNAcylation and chaperonin CCT5 protect OTX2 from aggregation in medulloblastoma cellsO-GlcNAcylation andanalysis of OTX2 O-GlcNac sites and dependent interactions
In this study, we demonstrated that OTX2 was transcriptionally and post-transcriptionally regulated by O-GlcNAcylation. We describe the modes of degradation of this essential homeobox protein involving both the proteasome and macroautophagy. While the proteasome remains the canonical degradation pat...
ORGANISM(S): Homo sapiens (Human) 
2024-01-22 | PXD040353 | Pride
Otx2 Ethcd-ms O-glcnac Interactome 
ProteomicsQuantitative Phosphoproteomics Reveals Crosstalk Between Phosphorylation and O-GlcNAc in the DNA Damage Response Pathway
The modification of intracellular proteins by monosaccharides of O-linked linked β-N-acetylglucosamine (O-GlcNAc) is thought to mediate proteins by regulating protein phosphorylation, either by modifying and modulating protein kinases or by competing with phosphorylation for hydroxyl residues. To pr...
ORGANISM(S): Mus musculus (Mouse) 
2015-01-28 | PXD001153 | Pride
Mouse embryonic fibroblast Atm Ogt knockout 
Unknown(μ-3,4-Diacetyl-hexa-2,4-diene-2,5-diol-ato-κO,O:O,O)bis-[aqua(1,10-phen-an-thro-line-κN,N')copper(II)] bis-(tetra-fluorid-oborate) monohydrate.
Not available
S-EPMC2969010 | biostudies-literature
UnknownElevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance.
Not available
S-EPMC3259902 | biostudies-literature
MetabolomicsPlasma Lipid Profile Reveals Plasmalogens as Potential Biomarkers for Colon Cancer Screening

In this era of precision medicine, there is an increasingly urgent need for highly sensitive tests for detecting tumors such as colon cancer (CC), a silent disease where the first symptoms may take 10-15 yr to appear. Mass spectrometry-based lipidomics is an emerging tool for such clinical diagno...

2023-11-13 | MTBLS1584 | MetaboLights
UnknownO-GlcNAcylation regulates OTX2's proteostasis.
Not available
S-EPMC10661118 | biostudies-literature
UnknownMolecular Recognition of GalNAc in Mucin-Type O-Glycosylation.
Not available
S-EPMC9996832 | biostudies-literature
ProteomicsHydrogen Deuterium Exchange Defines Catalytically Linked Regions of Protein Flexibility in the Catechol O-Methyltransferase Reaction
Human catechol-O-methyltransferase (COMT) has emerged as a model for understanding enzyme catalyzed methyl transfer from S-adenosylmethionine (AdoMet) to small molecule catecholate acceptors. Mutation of a single residue (Tyrosine 68) behind the methyl-bearing sulfonium of AdoMet was previously show...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-04-01 | MSV000085213 | MassIVE
ProteomicsThe O-GlcNAc transferase interaction network regulates the stress response
SILAC labeled mouse embryonic fibroblasts were treated with hydrogen peroxide to induce the stress reponse. OGT was immunoprecipitated and interactors identified via LC-MS/MS.
ORGANISM(S): Mus musculus (Mouse) 
2021-04-14 | PXD013645 | Pride
O-glcnac transferase Interactors Stress Lc-ms/ms 
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